Mehrizi Tahereh Zadeh, Ardestani Mehdi Shafiee, Kafiabad Sedigheh Amini
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Curr Drug Deliv. 2023;20(3):261-280. doi: 10.2174/1567201819666220513092020.
To obtain safe and qualified blood products (e.g., platelets, plasma, and red blood cells), various limitations such as limited shelf life (especially for platelets) and stability must be addressed. In this review study, the most commonly used metal nanomaterials (e.g., gold, silver, iron, and magnetic) reported in the literature from 2011 to 2021 were discussed owing to their unique properties, which provide exciting approaches to overcome these limitations and improve the stability, safety, and quality of blood products. Novelty: This study reviews for the first time the results of studies (from 2011 to 2021) that consider the effects of various metallic nanoparticles on the different blood products.
The results of this review study showed that some metallic nanoparticles are effective in improving the stability of plasma proteins. For this purpose, modified FeO magnetic nanoparticles and citrate-AuNPs protect albumin products against stressful situations. Also, SiO microspheres and silicacoated magnetite nanoparticles are highly capable of improving IgG stability. ZnO nanoparticles also reduced thrombin production, and protein-coated GMNP nanoparticles prevented unwanted leakage of factor VIII through blood vessels. Furthermore, the stability and longevity of erythrocytes can be improved by AuNP nanoparticles and Zr-based organic nanoparticles. In addition, platelet storage time can be improved using PEGylated Au and functionalized iron oxide nanoparticles.
According to the results of this study, it is suggested that further research should be conducted on metal nanoparticles as the most promising candidates to prepare metal nanoparticles with improved properties to increase the stability of various blood products.
为了获得安全且合格的血液制品（如血小板、血浆和红细胞），必须解决各种限制因素，如有限的保质期（尤其是血小板）和稳定性问题。在这项综述研究中，讨论了2011年至2021年文献中报道的最常用的金属纳米材料（如金、银、铁和磁性纳米材料），因其独特的性质，为克服这些限制以及提高血液制品的稳定性、安全性和质量提供了令人兴奋的方法。新颖性：本研究首次综述了（2011年至2021年）考虑各种金属纳米颗粒对不同血液制品影响的研究结果。
这项综述研究的结果表明，一些金属纳米颗粒在提高血浆蛋白稳定性方面是有效的。为此，改性的FeO磁性纳米颗粒和柠檬酸盐修饰的金纳米颗粒可保护白蛋白制品免受应激情况的影响。此外，SiO微球和二氧化硅包覆的磁铁矿纳米颗粒非常能够提高IgG的稳定性。ZnO纳米颗粒还减少了凝血酶的产生，蛋白质包覆的GMNP纳米颗粒可防止因子VIII通过血管意外泄漏。此外，金纳米颗粒和锆基有机纳米颗粒可提高红细胞的稳定性和寿命。此外，使用聚乙二醇化金和功能化氧化铁纳米颗粒可延长血小板的储存时间。
根据本研究的结果，建议对金属纳米颗粒进行进一步研究，作为制备具有改进性能以提高各种血液制品稳定性的最有前途的候选材料。
