Can Sevim Tuncer, Golbasi Hakan, Bayraktar Burak, Saglam Ceren, Omeroglu Ibrahim, Torun Raziye, Gercik Ilayda, Aktas Hale Ankara, Ekin Atalay
Department of Perinatology, Izmir City Hospital, Izmir, Turkey.
Department of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey.
J Clin Ultrasound. 2025 Jan;53(1):139-147. doi: 10.1002/jcu.23839. Epub 2024 Sep 20.
To examine the association between cavum septum pellucidum (CSP) and corpus callosum (CC) length and width measurements in mid-trimester sonographic screening in normal fetuses.
This prospective cohort study examined 152 pregnant women who underwent mid-trimester sonographic fetal anomaly screening. CSP and CC lengths and their anterior, middle, and posterior width measurements were examined sonographically. The association between length and width measurements of both structures, gestational week and CSP ratio (length/width) were evaluated.
The mean CSP length was 7.96 ± 1.09 mm, and the mean middle width was 3.43 ± 0.82 mm. The mean CC length was 20 ± 3.76 mm, and the mean middle width was 3.43 ± 0.82 mm. There was a positive correlation between CSP and CC lengths (r = 0.691, p < 0.001). There was also a significant correlation between CSP and CC anterior, middle and posterior widths (anterior (r = 0.366, p < 0.001), middle (r = 0.305, p < 0.001), and posterior (r = 0.233, p = 0.004)). All CSP and CC measurements were correlated with gestational age, biparietal diameter (BPD), and head circumference (HC) (p < 0.001, for all). The CSP ratio was not related to CC dimensions (p > 0.05, for all) and also decreased with the increase in BPD and HC dimensions (r = -0.186, p = 0.022, and r = -0.174, p = 0.032; respectively).
In normal fetuses, the length and width of the CC and CSP structures developed in relation to each other, as well as to the gestational week, BPD, and HC dimensions. In addition, while the CSP ratio was not found to be associated with CC dimensions, it decreased due to the increase in BPD and HC sizes.
研究孕中期超声筛查正常胎儿时透明隔腔（CSP）与胼胝体（CC）长度及宽度测量值之间的关联。
这项前瞻性队列研究对152例行孕中期胎儿超声异常筛查的孕妇进行了检查。通过超声检查CSP和CC的长度及其前、中、后宽度测量值。评估了这两个结构的长度和宽度测量值、孕周与CSP比率（长度/宽度）之间的关联。
CSP平均长度为7.96±1.09毫米，平均中部宽度为3.43±0.82毫米。CC平均长度为20±3.76毫米，平均中部宽度为3.43±0.82毫米。CSP与CC长度之间存在正相关（r = 0.691，p < 0.001）。CSP与CC的前、中、后宽度之间也存在显著相关性（前部（r = 0.366，p < 0.001），中部（r = 0.305，p < 0.001），后部（r = 0.233，p = 0.004））。所有CSP和CC测量值均与孕周、双顶径（BPD）和头围（HC）相关（所有p < 0.001）。CSP比率与CC尺寸无关（所有p > 0.05），并且随着BPD和HC尺寸的增加而降低（分别为r = -0.186，p = 0.022和r = -0.174，p = 0.032）。
在正常胎儿中，CC和CSP结构的长度和宽度相互关联，并且与孕周、BPD和HC尺寸相关。此外，虽然未发现CSP比率与CC尺寸相关，但由于BPD和HC尺寸的增加而降低。
