Bandhauer K, Spieler P
Eur Urol. 1985;11(4):224-7. doi: 10.1159/000472503.
In a prospective study 162 patients with localized or metastasizing carcinoma of the prostate were followed by fine-needle biopsies for cytological control of the therapy. 74 patients were treated by external beam irradiation (6,000-7,000 cGy rotation technique), 88 patients by hormone therapy. Cytologic regression grading was correlated with the clinical course during 3-6 years. The study shows a good correlation between the cytologic regression grade 1 year after irradiation and the clinical course. A poor regression grade (still visible tumor cells) 1 year after irradiation was followed by rapid tumor progression in more than 70%. In these cases early introduction of additional therapy should be considered. After hormone therapy the correlation of the cytologic regression grade with the clinical course is lower. Marked cytologic regression was associated with rapid tumor progression in about 60%, while poor regression grading was followed in about 50% by a satisfactory course. Fine-needle aspiration biopsy and grading of cytological regression is useful for follow-up of prostatic cancer after irradiation therapy. After hormone treatment, the grade of cytological regression does not reflect the prognosis of the disease sufficiently, thus other clinical, enzymatic and scintigraphic parameters have to be examined especially in cases with primary evidence of a metastasizing cancer of the prostate.
在一项前瞻性研究中，对162例局限性或转移性前列腺癌患者进行细针穿刺活检，以对治疗进行细胞学监测。74例患者接受外照射（6000 - 7000 cGy旋转技术），88例患者接受激素治疗。在3至6年期间，对细胞学消退分级与临床病程进行相关性分析。该研究表明，照射后1年的细胞学消退分级与临床病程之间具有良好的相关性。照射后1年消退分级较差（仍可见肿瘤细胞）的患者中，超过70%随后出现肿瘤快速进展。在这些病例中，应考虑尽早引入额外治疗。激素治疗后，细胞学消退分级与临床病程的相关性较低。明显的细胞学消退在约60%的病例中与肿瘤快速进展相关，而消退分级较差的病例中，约50%随后病程良好。细针穿刺活检及细胞学消退分级有助于前列腺癌放疗后的随访。激素治疗后，细胞学消退分级不能充分反映疾病预后，因此尤其在原发性前列腺转移癌的病例中，必须检查其他临床、酶学和闪烁显像参数。
