Nakato H, Shinomaya K, Mikawa H
Exp Pathol. 1985;28(2):97-104. doi: 10.1016/s0232-1513(85)80020-7.
The acute phase of arteritis of the common iliac artery induced in young rats by the inoculation of viable Erysipelothrix rhusiopathiae (E. rhusiopathiae) was examined. Within three days post inoculation, cell infiltration was first detected in the periarterial tissue, extending centripetally to the outer two-thirds of the media. However, the inner third of the media and the intima were free from cell infiltration, and the media showed no degeneration. E. rhusiopathiae first invaded the periarterial tissue and the adventitia, thereafter, invaded the outer two-thirds of the media, but not the inner third of the media or the intima. Invasion by the bacteria preceded cell infiltration. Arteritis was not induced by heat killed bacteria or the supernate from the culture medium. The arteritis was produced preferentially in large or medium-sized muscular arteries. Immunofluorescence test by FITC-conjugated peanut lectin demonstrated the desialated sites by the effect of the neuraminidase produced by E. rhusiopathiae in the arterial region that were concomitant with the invasion of the bacteria. C3 was also detected along the adventitia of the artery. The results demonstrated that viable E. rhusiopathiae can induce arteritis of muscular arteries and that the neuraminidase produced by the bacteria may play a role in the pathogenesis.
对通过接种活的猪丹毒丝菌（E. rhusiopathiae）在年轻大鼠中诱发的髂总动脉动脉炎急性期进行了检查。接种后三天内，首先在动脉周围组织中检测到细胞浸润，并向心性延伸至中膜外三分之二。然而，中膜内三分之一和内膜没有细胞浸润，中膜也没有退变。猪丹毒丝菌首先侵入动脉周围组织和外膜，此后侵入中膜外三分之二，但不侵入中膜内三分之一或内膜。细菌入侵先于细胞浸润。热灭活细菌或培养基上清液不会诱发动脉炎。动脉炎优先在大中型肌性动脉中产生。用异硫氰酸荧光素（FITC）偶联的花生凝集素进行的免疫荧光试验表明，在与细菌入侵相伴的动脉区域，猪丹毒丝菌产生的神经氨酸酶作用导致了去唾液酸化位点。沿动脉外膜也检测到了补体C3。结果表明，活的猪丹毒丝菌可诱发肌性动脉的动脉炎，且细菌产生的神经氨酸酶可能在发病机制中起作用。
