Shinomiya K, Nakato H
Int J Tissue React. 1985;7(4):267-71.
The acute phase of the arteritis of the common iliac artery induced in young rats by the inoculation of viable Erysipelothrix rhusiopathiae was examined. Arteritis of the common iliac artery was observed within 4 days after inoculation in every rat that was inoculated with the live bacteria. Within 2 days after the inoculation, infiltration by mononuclear and polymorphonuclear cells was first detected in the periarterial tissue extending centripetally to the outer two-thirds of the media. Invasion by the bacteria always preceded cell infiltration. Immunofluorescence test by FITC-labeled peanut lectin demonstrated the desialated sites by the effect of neuraminidase produced by the bacteria in the arterial wall concomitantly with the invasion of the bacteria. Linear presentation of C3 along the external elastic lamina of that artery was also detected. The results showed that viable E. rhusiopathiae could induce arteritis of muscular arteries and that the neuraminidase produced by the bacteria might play a role in the progress of arterial inflammation. We consider that this model will contribute to clarifying the progression of the arteritis process, and to assessing the efficacy of antiinflammatory drugs to inhibit the arterial inflammation.
对通过接种活的猪丹毒杆菌在幼年大鼠中诱发的髂总动脉动脉炎急性期进行了检查。在每只接种活菌的大鼠中，接种后4天内观察到髂总动脉动脉炎。接种后2天内，首先在向中膜外三分之二向心性延伸的动脉周围组织中检测到单核细胞和多形核细胞浸润。细菌入侵总是先于细胞浸润。用异硫氰酸荧光素标记的花生凝集素进行的免疫荧光试验表明，随着细菌入侵，动脉壁中细菌产生的神经氨酸酶作用导致了去唾液酸化位点。还检测到该动脉外弹性膜沿线C3呈线性分布。结果表明，活的猪丹毒杆菌可诱发肌性动脉动脉炎，细菌产生的神经氨酸酶可能在动脉炎症进展中起作用。我们认为该模型将有助于阐明动脉炎过程的进展，并有助于评估抗炎药物抑制动脉炎症的疗效。
