Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic Barcelona, Spain.
Fundació Recerca Clínic Barcelona-Institut d'Investigació Biomèdica August Pi i Sunyer, Spain.
J Speech Lang Hear Res. 2024 Oct 8;67(10):3762-3777. doi: 10.1044/2024_JSLHR-23-00583. Epub 2024 Sep 20.
Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by worsening of speech and/or language. Script training intervention promotes automatized speech production via repeated practice of scripted content. This study evaluated the acceptability, feasibility, and effects of a modified version of Video-Implemented Script Training for Aphasia (VISTA) in the three PPA variants and compared outcomes by intervention modality (teletherapy vs. in person).
Thirteen bilingual (Spanish-Catalan) participants were included (semantic variant, = 5; logopenic variant, = 5; nonfluent/agrammatic variant, = 3; teletherapy, = 7). Using a nonrandomized design, intervention was administered in participants' dominant language. Participants were trained on an individualized script twice per week, over 8 weeks. Performance on measures related to script accuracy, content, and subjective ratings of production quality was evaluated at baseline, immediately post, and at 3 and 6 months post-intervention.
No significant differences were observed on the basis of intervention modality. Participants demonstrated significant improvements from pre- to post-intervention in script production, synonym production, keywords, and global quality on the trained script. Maintenance was observed when comparing performance at post-intervention relative to 3- and 6-month follow-up for script and synonym production. Significant improvement in production quality of the untrained topic was observed following intervention. Different patterns of benefit were observed by PPA variant.
Modified VISTA was acceptable and effective across the three PPA variants, as evidenced by improvements on a broader array of outcome measures than those previously reported. Findings also provide further support for provision for teletherapy in individuals with PPA.
原发性进行性失语症（PPA）是一种神经退行性疾病，其特征是言语和/或语言功能逐渐恶化。脚本训练干预通过重复练习脚本内容来促进自动化言语产生。本研究评估了经过修改的视频实施脚本训练治疗失语症（VISTA）在三种 PPA 变体中的可接受性、可行性和效果，并比较了两种干预模式（远程治疗与面对面治疗）的结果。
共纳入 13 名双语（西班牙语-加泰罗尼亚语）参与者（语义变体，n = 5；语义流畅型失语症，n = 5；非流畅/语法障碍型失语症，n = 3；远程治疗，n = 7）。采用非随机设计，在参与者的主导语言中进行干预。参与者每周接受两次个性化脚本训练，共 8 周。在基线、干预后即刻以及干预后 3 个月和 6 个月，使用与脚本准确性、内容相关的测量方法以及对生产质量的主观评价来评估患者的表现。
干预模式无显著差异。与基线相比，参与者在脚本生成、同义词生成、关键词和训练脚本的整体质量方面的表现，在干预后即刻有显著提高。与干预后即刻相比，在 3 个月和 6 个月的随访中，脚本和同义词生成的表现保持不变。干预后，未训练主题的生产质量也有显著提高。不同的 PPA 变体表现出不同的受益模式。
经过修改的 VISTA 在三种 PPA 变体中是可以接受和有效的，这表现在与之前报道的结果相比，有更广泛的测量指标得到改善。研究结果还为 PPA 患者提供远程治疗提供了进一步支持。
