Masood Anum, Khan Mohsin Abbas, Bhat Mashooq A, Awan Breena, Hanif Ramsha, Raza Asim, Khaliq Saharish, Ahmed Javaid, Ullah Farhat
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The islamia University of Bahawalpur, P.O Box 63100, Pakistan.
Institute of Pharmaceutical Science, Faculty of Life Science and Medicine, King's College, London, SE1 9NH, UK.
Future Med Chem. 2024;16(22):2383-2394. doi: 10.1080/17568919.2024.2401313. Epub 2024 Sep 20.
Calcium channel antagonists are of considerable interest in treating elevated blood pressure and its pathologies. Schiff base derivatives of amlodipine were produced to check its urease inhibition potentials as well antibacterial and antioxidant activities. Structural illustration along with chemical characterization were achieved by spectral techniques (H NMR, FTIR, C NMR) and docking studies also performed. 3g displayed remarkable anti-hypertensive activity compared with parent drug. 3b, 3f and 3g showed urease inhibition potentials. These compounds can aid as lead for further investigations since they exhibited comparable or superior interactions.
钙通道拮抗剂在治疗高血压及其相关病症方面备受关注。制备了氨氯地平的席夫碱衍生物，以检测其脲酶抑制潜力以及抗菌和抗氧化活性。通过光谱技术（氢核磁共振、傅里叶变换红外光谱、碳核磁共振）进行了结构说明和化学表征，还进行了对接研究。与母体药物相比，3g显示出显著的抗高血压活性。3b、3f和3g表现出脲酶抑制潜力。由于这些化合物表现出相当或更好的相互作用，它们可作为进一步研究的先导。
