完成未完成的任务：Chd1 与 FACT 一起解析六聚体-核小体复合物。
Finish the unfinished: Chd1 resolving hexasome-nucleosome complex with FACT.
机构信息
School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China.
School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China.
出版信息
Mol Cell. 2024 Sep 19;84(18):3371-3373. doi: 10.1016/j.molcel.2024.08.031.
In this issue of Molecular Cell, Engeholm et al. present cryo-EM structures of the chromatin remodeler Chd1 bound to a hexasome-nucleosome complex, an intermediate state during transcription either with or without FACT to restore the missing H2A-H2B dimer. These two binding modes reveal how Chd1 and FACT cooperate in nucleosome re-establishment during transcription.
在本期《分子细胞》中，Engeholm 等人展示了染色质重塑酶 Chd1 与六聚体-核小体复合物结合的冷冻电镜结构，这是转录过程中的一个中间状态，无论是有还是没有 FACT 来恢复缺失的 H2A-H2B 二聚体。这两种结合模式揭示了 Chd1 和 FACT 如何在转录过程中合作重建核小体。
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