Inserm U1194, Institut de recherche en cancérologie de Montpellier (IRCM), université de Montpellier, avenue des Apothicaires, 34298 Montpellier, France; Fédération universitaire d'oncologie radiothérapie, Institut régional du cancer de Montpellier (ICM), rue Croix-Verte, 34298 Montpellier, France; Fédération universitaire d'oncologie radiothérapie, Institut de cancérologie du Gard, CHU de Nîmes, rue Henri-Pujol, 30000 Nîmes, France.
Inserm U1194, Institut de recherche en cancérologie de Montpellier (IRCM), université de Montpellier, avenue des Apothicaires, 34298 Montpellier, France; Fédération universitaire d'oncologie radiothérapie, Institut régional du cancer de Montpellier (ICM), rue Croix-Verte, 34298 Montpellier, France.
Cancer Radiother. 2024 Oct;28(5):442-448. doi: 10.1016/j.canrad.2024.06.002. Epub 2024 Sep 19.
The impact of curative radiotherapy mainly depends on the total dose delivered to the tumor. However, despite recent technological advances, the dose delivered to surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In the same population treated at one center with the same technique, individual radiosensitivity clearly exists, particularly in terms of late side effects that are, in principle, non-reversible. This article details the history of the radiation-induced lymphocyte apoptosis assay, from preclinical data to multicenter clinical trials. It puts the performance of such assays into perspective to define the optimal clinical situations for its use in daily practice.
根治性放疗的效果主要取决于肿瘤所接受的总剂量。然而，尽管最近技术有所进步，但周围健康组织所接受的剂量可能会降低许多放射治疗的治疗效果。在同一中心使用相同技术治疗的同一人群中，个体的放射敏感性显然存在，特别是在原则上不可逆转的晚期副作用方面。本文详细介绍了辐射诱导的淋巴细胞凋亡检测法的历史，从临床前数据到多中心临床试验。它评估了这些检测法的性能，以确定其在日常实践中最佳的应用情况。
