Tajima K, Hirose K, Nakagawa N, Kuroishi T, Tominaga S
Jpn J Cancer Res. 1985 Aug;76(8):717-28.
In order to study the effect of urbanization on the epidemiological features of colo-rectal cancer in Japan, the age-adjusted death rates (AADRs) for right-sided (cecum, ascending and transverse) colon, left-sided (descending and sigmoid) colon and rectum cancers during three periods, 1969-71, 1974-76 and 1979-81, were compared among five areas with different population sizes; ten metropolitan cities (greater than 1,000,000), large cities (1,000,000-150,000), medium-sized cities (150,000-50,000), small cities (less than 50,000) and counties. The AADR for left-sided colon cancer has been increasing in recent years, especially in males, and was higher in urban areas than in rural areas, which may imply that the recent increase in the incidence of left-sided colon cancer is associated with an urbanization of the life styles of Japanese people. In Japan, the daily consumption of carbohydrate has been decreasing, but that of total fat has been increasing in recent years, and the ratio of fat/carbohydrate consumption as an energy source was strongly correlated with the AADRs for left-sided colon cancer among the five areas in the three periods. From this correlation analysis, it was suggested that urbanization of life style, namely, the recent westernization of eating habits of Japanese people might be associated with the recent increase of the AADRs for colon cancer, especially of left-sided colon cancer, in Japan.
为研究城市化对日本结直肠癌流行病学特征的影响，比较了1969 - 71年、1974 - 76年和1979 - 81年三个时期，五个不同人口规模地区（10个大城市（人口超过100万）、大城市（100万 - 15万）、中等城市（15万 - 5万）、小城市（人口少于5万）及乡村）右侧（盲肠、升结肠和横结肠）结肠癌、左侧（降结肠和乙状结肠）结肠癌和直肠癌的年龄调整死亡率（AADR）。近年来，左侧结肠癌的AADR一直在上升，尤其是男性，且城市地区高于农村地区，这可能意味着近期左侧结肠癌发病率的上升与日本人生活方式的城市化有关。在日本，碳水化合物的日摄入量一直在下降，但近年来总脂肪摄入量一直在增加，在三个时期的五个地区中，作为能量来源的脂肪/碳水化合物消费比例与左侧结肠癌的AADR密切相关。通过这种相关性分析表明，生活方式的城市化，即日本人近期饮食习惯的西化，可能与日本近期结肠癌尤其是左侧结肠癌的AADR上升有关。
