Jin Xuefeng, Tong Wenhui, Sun Li, Lu Sujue, Xu Tiantian, Sun Pan, Liu Yan, Li Hangxu
Medical College of Jinzhou Medical University, Jinzhou, Liaoning, China.
Medical College of Yangzhou University, Yangzhou, Jiangsu, China.
Front Nutr. 2024 Dec 20;11:1514320. doi: 10.3389/fnut.2024.1514320. eCollection 2024.
Urinary incontinence (UI), particularly urge urinary incontinence (UUI), is a prevalent condition that worsens with age and negatively affects quality of life. Antioxidants, measured by the composite dietary antioxidant index (CDAI), have been linked to inflammation and other diseases, but their relationship with UUI remains uncertain. The purpose of this study is to investigate the relationship between UUI prevalence and CDAI.
Data for this cross-sectional study were obtained from the National Health and Nutrition Examination Survey's four cycles (2011-2018). The odds ratio (OR) and 95% confidence interval (95% CI) of the relationship between CDAI and male UUI were ascertained by the use of weighted univariate analysis, multivariate logistic regression, restricted cubic spline regression, and subgroup analysis. PSM and sensitivity analyses were performed to assess the robustness of the findings.
A total of 7,735 participants took part in this study. After adjusting for potential confounders, CDAI was found to be negatively associated with the prevalence of UUI in those with lower CDAI (about half overall). This relationship lost significance in populations with higher CDAI. The negative correlation between zinc and the prevalence of UUI was more significant in populations with low antioxidant diets. The results remained consistent, with subgroup analyses finding a significant interaction effect for race only after PSM ( = 0.043), with no significant interaction effect observed for the rest.
This study showed a negative correlation between CDAI and UUI incidence in the group of men with low CDAI levels (about half of the population). Thus, effective prevention or treatment of UUI requires dietary changes aimed at the male population with poor antioxidant diets.
尿失禁（UI），尤其是急迫性尿失禁（UUI），是一种常见疾病，会随着年龄增长而恶化，并对生活质量产生负面影响。通过综合饮食抗氧化指数（CDAI）衡量的抗氧化剂与炎症及其他疾病有关，但其与UUI的关系仍不确定。本研究的目的是调查UUI患病率与CDAI之间的关系。
本横断面研究的数据来自国家健康与营养检查调查的四个周期（2011 - 2018年）。通过加权单变量分析、多因素逻辑回归、受限立方样条回归和亚组分析确定CDAI与男性UUI之间关系的比值比（OR）和95%置信区间（95%CI）。进行倾向得分匹配（PSM）和敏感性分析以评估研究结果的稳健性。
共有7735名参与者参与了本研究。在调整潜在混杂因素后，发现CDAI较低（约占总体一半）的人群中，CDAI与UUI患病率呈负相关。在CDAI较高的人群中，这种关系失去了显著性。在抗氧化剂饮食较低的人群中，锌与UUI患病率之间的负相关性更为显著。结果保持一致，亚组分析仅在PSM后发现种族存在显著交互作用（P = 0.043），其余未观察到显著交互作用。
本研究表明，在CDAI水平较低的男性群体（约占总体一半）中，CDAI与UUI发病率呈负相关。因此，有效预防或治疗UUI需要针对抗氧化剂饮食较差的男性人群进行饮食调整。
