Department of Critical Care Medicine, School of Anesthesiology, Naval Medical University, Shanghai, 200433, China.
Department of Pharmacy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Crit Care. 2024 Sep 20;28(1):315. doi: 10.1186/s13054-024-05099-4.
This narrative review provides an overview of the evolving significance of lymphopenia in sepsis, emphasizing its critical function in this complex and heterogeneous disease. We describe the causal relationship of lymphopenia with clinical outcomes, sustained immunosuppression, and its correlation with sepsis prediction markers and therapeutic targets. The primary mechanisms of septic lymphopenia are highlighted. In addition, the paper summarizes various attempts to treat lymphopenia and highlights the practical significance of promoting lymphocyte proliferation as the next research direction.
这篇叙述性综述概述了淋巴细胞减少症在脓毒症中的重要性，强调了其在这种复杂和异质性疾病中的关键作用。我们描述了淋巴细胞减少症与临床结局、持续免疫抑制以及与脓毒症预测标志物和治疗靶点的相关性的因果关系。强调了脓毒性淋巴细胞减少症的主要机制。此外，本文还总结了治疗淋巴细胞减少症的各种尝试，并强调了促进淋巴细胞增殖作为下一个研究方向的实际意义。
