Smith M W
J Cell Physiol. 1985 Aug;124(2):219-25. doi: 10.1002/jcp.1041240208.
Developmental profiles describing the expression of lactase, alpha-glucosidase, and alkaline phosphatase activities have been determined quantitatively in mouse jejunal enterocytes during migration over villi and Peyer's patch lymphoid tissue. The predicted maximal lactase and alpha-glucosidase activities expressed by enterocytes migrating over Peyer's patch follicles were about one-quarter and one-half of values found in control villi. Alkaline phosphatase activity was, on the other hand, one third greater in Peyer's patch compared with villus enterocytes. Expression of lactase and alpha-glucosidase activities was initially less in enterocytes migrating along interfollicular compared with control villi. Subsequent increase in hydrolase activities occurred during the later stages of enterocyte migration over interfollicular villi. Lactase activity in athymic mice Peyer's patch enterocytes was identical to that recorded for control mice. The corresponding value for villus lactase was, however, only half that found in control tissue. Factors produced locally in lymphoid follicles are probably responsible for selective effects on enterocyte differentiation.
在小鼠空肠肠上皮细胞迁移至绒毛和派尔集合淋巴结淋巴组织的过程中，已对描述乳糖酶、α-葡萄糖苷酶和碱性磷酸酶活性表达的发育概况进行了定量测定。迁移至派尔集合淋巴结滤泡上的肠上皮细胞所表达的预测最大乳糖酶和α-葡萄糖苷酶活性，约为对照绒毛中所发现值的四分之一和二分之一。另一方面，与绒毛肠上皮细胞相比，派尔集合淋巴结中的碱性磷酸酶活性高三分之一。与对照绒毛相比，沿滤泡间迁移的肠上皮细胞中乳糖酶和α-葡萄糖苷酶活性最初较低。水解酶活性的后续增加发生在肠上皮细胞迁移至滤泡间绒毛的后期阶段。无胸腺小鼠派尔集合淋巴结肠上皮细胞中的乳糖酶活性与对照小鼠所记录的相同。然而，绒毛乳糖酶的相应值仅为对照组织中所发现值的一半。淋巴滤泡中局部产生的因子可能对肠上皮细胞分化产生选择性影响。
