School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Phytomedicine. 2024 Dec;135:156062. doi: 10.1016/j.phymed.2024.156062. Epub 2024 Sep 16.
Pulmonary hypertension (PH) is a rare cardiovascular disease with high morbidity and mortality rates. It is characterized by increased pulmonary arterial pressure. Current research into relevant therapeutic drugs and targets for PH, however, is insufficient still. Traditional Chinese medicine (TCM) and natural products have a long history as therapeutics for PH. Network pharmacology is an approach that integrates drug-target interactions and signaling pathways based on biomarkers information obtained from drug and disease databases. The concept of network pharmacology shows many similarities with the TCM philosophy. Network pharmacology help elucidate the mechanisms of TCM in PH. This review presents representative applications of network pharmacology in the study of the mechanisms of TCM and natural products for the treatment of PH.
In this review, we used ("pulmonary hypertension" OR "pulmonary arterial hypertension" OR "chronic thromboembolic pulmonary hypertension") AND ("network pharmacology" OR "systematic pharmacology") as keywords to search for reports from PubMed, Web of Science, and Google Scholar databases from ten years ago. The studies were screened and those chosen are summarized here. The TCM and natural products inPH and their corresponding targets and signaling pathways are described. Additionally, we discuss the application of network pharmacology in the study of TCM in PH to provide insights for future application strategies.
Network pharmacology have shown that AKT-related pathways, HIF-1 signaling pathway, MAPK signaling pathway, TGF-β-Smad pathway, cell cycle-related pathways and inflammation-related pathways are the main signaling pathways enriched in the PH targets of TCM. Reservatrol, curcumol, genistin, formononetin, wogonin, luteolin, baicalein, berberine, triptolide and tanshinone llA are active ingredients specific for PH treatment. A number of databases and tools specific for the treatment of PH are used in network pharmacology and natural product research.
Through the reasonable combination of molecular docking, omics technology and bioinformatics technology, the mechanism of multi-targets can be explained more comprehensively. Analyzing the complex mechanism of TCM from the clinical perspective may be a potential development trend of network pharmacology. Combination of predicted targets and traditional pharmacology improves efficiency of drug development.
肺动脉高压（PH）是一种罕见的心血管疾病，发病率和死亡率都很高。其特征是肺动脉压升高。然而，目前对 PH 相关治疗药物和靶点的研究仍然不足。中药（TCM）和天然产物作为 PH 的治疗方法已有很长的历史。网络药理学是一种基于药物和疾病数据库中获得的生物标志物信息整合药物-靶标相互作用和信号通路的方法。网络药理学的概念与 TCM 哲学有许多相似之处。网络药理学有助于阐明 TCM 在 PH 中的作用机制。本综述介绍了网络药理学在研究 TCM 和天然产物治疗 PH 的机制方面的代表性应用。
在本综述中，我们使用“肺动脉高压”或“肺动脉高血压”或“慢性血栓栓塞性肺动脉高压”和“网络药理学”或“系统药理学”作为关键词，从 PubMed、Web of Science 和 Google Scholar 数据库中搜索十年前的报告。筛选研究并总结如下。描述了 PH 中的 TCM 和天然产物及其相应的靶标和信号通路。此外，我们还讨论了网络药理学在 TCM 研究中的应用，为未来的应用策略提供了思路。
网络药理学表明，AKT 相关途径、HIF-1 信号通路、MAPK 信号通路、TGF-β-Smad 通路、细胞周期相关通路和炎症相关通路是 TCM 治疗 PH 的主要信号通路。白藜芦醇、姜黄素、染料木素、芒柄花素、汉黄芩素、木犀草素、黄芩素、小檗碱、雷公藤内酯和丹参酮 IIA 是治疗 PH 的特定活性成分。网络药理学和天然产物研究中使用了许多针对 PH 治疗的数据库和工具。
通过合理结合分子对接、组学技术和生物信息学技术，可以更全面地解释多靶点的作用机制。从临床角度分析 TCM 的复杂机制可能是网络药理学的一个潜在发展趋势。预测靶标与传统药理学的结合提高了药物开发的效率。
