Wang Kaijun, Yin Jie, Chen Jiayi, Ma Jie, Si Hongbin, Xia Diqi
College of Animal Science and Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530004, China; Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Phytomedicine. 2024 Jun;128:155258. doi: 10.1016/j.phymed.2023.155258. Epub 2024 Jan 11.
Traditional Chinese Medicine (TCM), renowned for its holistic approach with a 2000-year history of utilizing natural remedies, offers unique advantages in disease prevention and treatment. Berberine, found in various Chinese herbs, has been employed for many years, primarily for addressing conditions such as diarrhea and dysentery. Berberine has recently become a research focus owing to its pharmacological activities and benefits to human bodies. However, little is known about the anti-inflammatory mechanism of berberine.
To summarize recent findings regarding the pharmacological effects and mechanisms of berberine anti-inflammation and highlight and predict the potential therapeutic effects and systematic mechanism of berberine.
Recent studies (2013-2023) on the pharmacological effects and mechanisms of berberine anti-inflammation were retrieved from Web of Science, PubMed, Google Scholar, and Scopus up to July 2023 using relevant keywords. Network pharmacology and bioinformatics analysis were employed to predict the therapeutic effects and mechanisms of berberine against potential diseases.
The related pharmacological mechanisms of berberine anti-inflammation include the inhibition of inflammatory cytokine production (e.g., IL-1β, IL-6, TNF-α), thereby attenuating the inflammatory response; Inhibiting the activation of NF-κB signaling pathway and IκBα degradation; Inhibiting the activation of MAPK signaling pathway; Enhancing the activation of the STAT1 signaling pathway; Berberine interacts directly with cell membranes through a variety of pathways, thereby influencing cellular physiological activities. Berberine enhances human immunity and modulates immune system function, which is integral to addressing certain autoimmune and tumour-related health concerns.
This study expounds on the correlation between berberine and inflammatory diseases, encapsulating the mechanisms through which berberine treats select typical inflammatory ailments. Furthermore, it delves into a deeper understanding of berberine's effectiveness by integrating network pharmacology and molecular docking techniques in the context of treating inflammatory diseases. It provides guidance and reference for berberine's subsequent revelation of the modern scientific connotation of Chinese medicine.
传统中医以其整体疗法和使用天然药物的2000年历史而闻名，在疾病预防和治疗方面具有独特优势。黄连素存在于多种中草药中，多年来一直被用于治疗腹泻和痢疾等病症。由于其药理活性和对人体的益处，黄连素最近成为研究热点。然而，关于黄连素的抗炎机制知之甚少。
总结黄连素抗炎药理作用和机制的最新研究成果，突出并预测黄连素的潜在治疗作用及系统机制。
截至2023年7月，使用相关关键词从Web of Science、PubMed、谷歌学术和Scopus中检索2013 - 2023年关于黄连素抗炎药理作用和机制的最新研究。采用网络药理学和生物信息学分析来预测黄连素对潜在疾病的治疗作用和机制。
黄连素抗炎的相关药理机制包括抑制炎性细胞因子产生（如IL - 1β、IL - 6、TNF - α），从而减轻炎症反应；抑制NF - κB信号通路的激活和IκBα降解；抑制MAPK信号通路的激活；增强STAT1信号通路的激活；黄连素通过多种途径直接与细胞膜相互作用，从而影响细胞生理活动。黄连素增强人体免疫力并调节免疫系统功能，这对于解决某些自身免疫和肿瘤相关的健康问题至关重要。
本研究阐述了黄连素与炎症性疾病之间的相关性，概括了黄连素治疗某些典型炎症性疾病的机制。此外，通过在治疗炎症性疾病的背景下整合网络药理学和分子对接技术，更深入地了解了黄连素的有效性。它为黄连素后续揭示中医的现代科学内涵提供了指导和参考。
