Karlsson F A, Hardell L I, Hellsing K
Acta Paediatr Scand. 1979 Sep;68(5):663-7. doi: 10.1111/j.1651-2227.1979.tb18435.x.
Urinary concentrations of protein, albumin, beta 2-microglobulin, alpha-amino nitrogen, and creatinine were determined in forty-one full-term infants on seven occasions up to six months of age. Except for beta 2-microglobulin the concentrations were highest on the first day, followed by a rapid decrease to a constant level within two weeks. Protein diminished approximately seven-fold, albumin twenty-fold, alpha-amino nitrogen three-fold and creatinine five-fold. By contrast, beta 2-microglobulin, a low molecular weight protein, first increased three-fold between day 1 and day 5, thereafter decreasing slowly 17-fold during the first three months of age. The data indicate that different kidney functions mature asynchronously.
对41名足月婴儿在6个月龄以内分7次测定其尿中蛋白质、白蛋白、β2-微球蛋白、α-氨基氮和肌酐的浓度。除β2-微球蛋白外，其他物质的浓度在出生第一天最高，随后迅速下降，在两周内降至恒定水平。蛋白质浓度下降约7倍，白蛋白下降20倍，α-氨基氮下降3倍，肌酐下降5倍。相比之下，β2-微球蛋白是一种低分子量蛋白质，在出生第1天到第5天之间先增加3倍，此后在3个月龄内缓慢下降17倍。数据表明，不同的肾功能成熟并不同步。
