Institute for Advancing Health Through Agriculture, Texas A&M Agrilife Research, 17360 Coit Road, Dallas, TX, 75252, US.
Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, US.
J Behav Med. 2024 Dec;47(6):1002-1011. doi: 10.1007/s10865-024-00518-x. Epub 2024 Sep 21.
Multiple intervention strategies have been found effective for increasing physical activity among breast cancer survivors, yet most breast cancer survivors fail to meet physical activity recommendations. Optimization of interventions can facilitate real word implementation to ensure effective and efficient intervention delivery. Using a full-factorial design based on the Multiphase Optimization Strategy, 337 breast cancer survivors were randomized to receive a combination of four intervention components: (1) supervised exercise sessions, (2) facility membership, (3) Active Living Every Day (ALED), and (4) Fitbit. Moderate-to vigorous (MVPA) and light-intensity physical activity (LPA) were measured at baseline, 3 months, and 6 months with a hip-worn Actigraph GT3X+. Normal linear mixed models with separate intercepts for each subject were fit in the SAS 9.4 Mixed procedure. Participants who received supervised exercise sessions engaged in more MVPA, 153.58 min/week vs. 133.0 min/week (F = 3.97, p = 0.048) and LPA, 170.26 min/day versus 160.98 light PA minutes/day (F = 4.67, p = 0.032), compared to participants who did not receive supervised exercise. The effects of the three other intervention components on MVPA were not significant; however, those that received ALED engaged in less LPA (F = 6.6, p = 0.011). Supervised exercise sessions resulted in significant increases in MVPA and LPA in a sample of breast cancer survivors. Of note, these sessions were provided only during the first 6 weeks of the intervention and effects remained significant at 6 months. Results of this trial could inform future implementation efforts to ensure effective and efficient delivery of physical activity programs for breast cancer survivors.
多项干预策略已被证实可有效增加乳腺癌幸存者的身体活动量，但大多数乳腺癌幸存者仍未达到身体活动建议量。干预措施的优化可以促进实际实施，以确保干预措施的有效和高效实施。本研究采用基于多相优化策略的完全因子设计，将 337 例乳腺癌幸存者随机分为四组，分别接受以下四种干预措施的组合：（1）监督锻炼课程，（2）设施会员，（3）日常积极生活（ALED）和（4）Fitbit。在基线、3 个月和 6 个月时，使用佩戴在臀部的 Actigraph GT3X+测量中度至剧烈（MVPA）和低强度体力活动（LPA）。使用 SAS 9.4 混合程序中的混合模型分别为每个个体拟合正常线性混合模型。与未接受监督锻炼的参与者相比，接受监督锻炼的参与者进行了更多的 MVPA，分别为 153.58 分钟/周和 133.0 分钟/周（F=3.97，p=0.048）和 LPA，分别为 170.26 分钟/天和 160.98 分钟/天（F=4.67，p=0.032）。其他三个干预措施对 MVPA 的影响不显著；然而，接受 ALED 的参与者的 LPA 减少（F=6.6，p=0.011）。监督锻炼课程可显著增加乳腺癌幸存者的 MVPA 和 LPA。值得注意的是，这些课程仅在干预的前 6 周内提供，并且在 6 个月时仍保持显著效果。本试验结果可为未来实施工作提供信息，以确保为乳腺癌幸存者提供有效和高效的身体活动方案。
