评估全身双能X线吸收法(DEXA)与生物电阻抗分析(BIA)肌肉测量值之间相关性的开放性、活性对照临床研究。
Open, Active-Controlled Clinical Study to Evaluate the Correlation between Whole Body DEXA and BIA Muscle Measurements.
作者信息
Ha Yong-Chan, Kim Shinjune, Yoo Jun-Il
机构信息
Department of Orthopaedic Surgery, Seoul Bumin Hospital, Seoul, Korea.
Department of Biomedical Research Institute, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
出版信息
J Bone Metab. 2024 Aug;31(3):219-227. doi: 10.11005/jbm.2024.31.3.219. Epub 2024 Aug 31.
BACKGROUND
Dual energy X-ray absorptiometry (DXA) is the gold standard for diagnosing sarcopenia. However, comparative studies using bioelectrical impedance analysis (BIA) would be required in the Korean population. This study aimed to evaluate the correlation between total-body bone density measuring devices (Hologic and GE Lunar) and a bioelectrical impedance measurement device (InBody 970) as well as the correlation between upper body muscle mass.
METHODS
A total of 119 participants were involved in this study, aged 20 to 70 years, with specific body mass index ranges and no severe health conditions used both DXA (or DEXA) and BIA technologies to assess body composition. The participants were scanned using a Hologic QDR-4500W DXA scanner and GE-Lunar Prodigy DXA systems, and the InBody 970 type of multi-frequency BIA machine. Statistical analysis was performed to determine the correlation between the devices, with a coefficient of at least 0.8.
RESULTS
The muscle mass measurement comparisons between the InBody 970 and Hologic devices demonstrated remarkably high correlation coefficients (exceeding 0.9) across all limbs. Similarly, the muscle mass comparison between the Inbody 970 and GE Lunar devices also revealed substantial correlation coefficients, ranging from 0.83 upwards, across all limbs.
CONCLUSIONS
Limb muscle mass measurements using Hologic and GE Lunar whole-body DXA and Inbody 970 BIA demonstrated particularly high levels of concordance. In addition, a conversion formula that bridges limb muscle mass measurements from two widely used whole-body DXA machines and a BIA machine will facilitate sarcopenia research and patient management.
背景
双能X线吸收法(DXA)是诊断肌肉减少症的金标准。然而,韩国人群需要使用生物电阻抗分析(BIA)进行对比研究。本研究旨在评估全身骨密度测量设备(Hologic和GE Lunar)与生物电阻抗测量设备(InBody 970)之间的相关性,以及上身肌肉质量之间的相关性。
方法
本研究共纳入119名参与者,年龄在20至70岁之间,具有特定的体重指数范围且无严重健康问题,使用DXA(或DEXA)和BIA技术评估身体成分。参与者使用Hologic QDR - 4500W DXA扫描仪、GE - Lunar Prodigy DXA系统以及InBody 970型多频BIA机器进行扫描。进行统计分析以确定设备之间的相关性,系数至少为0.8。
结果
InBody 970与Hologic设备之间的肌肉质量测量比较显示,所有肢体的相关系数均非常高(超过0.9)。同样,Inbody 970与GE Lunar设备之间的肌肉质量比较也显示,所有肢体的相关系数也很高,从0.83以上不等。
结论
使用Hologic和GE Lunar全身DXA以及Inbody 970 BIA进行肢体肌肉质量测量显示出特别高的一致性水平。此外,一个连接两种广泛使用的全身DXA机器和一种BIA机器的肢体肌肉质量测量的转换公式将有助于肌肉减少症的研究和患者管理。