[基于组学的生物衰老时钟及其应用研究]

[A research of omics-based biological aging clocks and their applications].

作者信息

Zhu Z W, Cheng S S, Cheng X, Chen W H, Wang C L

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2024 Sep 10;45(9):1291-1301. doi: 10.3760/cma.j.cn112338-20240424-00215.

DOI:10.3760/cma.j.cn112338-20240424-00215

PMID:39307704

Abstract

Aging, a process of functional decline with the increase of chronological age, is a major risk factor for chronic diseases. Aging shows significant individual differences, which is influenced by both genetic and environmental factors. Accurate measurement of physiological age helps identify individuals with accelerated aging and those at high risk for chronic diseases and mortality, which would promote individual health management and precision medicine for healthy aging. In this paper, we summarize the omics-based aging clocks and discuss their current and future applications.

摘要

衰老，是一个随着实际年龄增长而功能衰退的过程，是慢性疾病的主要风险因素。衰老存在显著的个体差异，受遗传和环境因素的双重影响。准确测量生理年龄有助于识别衰老加速的个体以及患慢性疾病和死亡风险较高的个体，这将促进个体健康管理和健康老龄化的精准医学发展。在本文中，我们总结了基于组学的衰老时钟，并讨论了它们的当前及未来应用。