Doko F
Jpn J Antibiot. 1985 May;38(5):1301-3.
In patients with carcinoma of the uterine cervix, cefminox (CMNX, MT-141) was given intravenously after panhysterectomy and the pelvic dead space exudate and serum levels of the drug were determined at various periods. The pelvic dead space exudate level reached its peak of 67.21 +/- 39.81 micrograms/ml at 2 hours, which decreased gradually to 26.04 +/- 6.66 micrograms/ml at 6 hours. In the serum, the drug level attained the peak of 152.98 +/- 85.37 of 7.26 +/- 1.66 micrograms/ml was still detected. The pelvic dead space exudate level was much higher than its MIC or 3h-MBC at all periods studied. From these results it was considered that CMNX achieves levels high enough to be expected of clinical efficacy in the pelvic dead space exudate and serum.
对于子宫颈癌患者，在全子宫切除术后静脉注射头孢米诺（CMNX，MT - 141），并在不同时间段测定盆腔死腔渗出液和血清中的药物水平。盆腔死腔渗出液水平在2小时时达到峰值，为67.21±39.81微克/毫升，6小时时逐渐降至26.04±6.66微克/毫升。血清中，药物水平在7.26±1.66微克/毫升时达到峰值152.98±85.37，6小时时仍可检测到。在所有研究时间段，盆腔死腔渗出液水平均远高于其最低抑菌浓度（MIC）或3小时最低杀菌浓度（3h - MBC）。从这些结果来看，认为头孢米诺在盆腔死腔渗出液和血清中可达到足以预期临床疗效的水平。
