O'Dea Michael R, Hasel Philip
Neuroscience Institute, NYU Grossman School of Medicine, New York, New York, USA.
UK Dementia Research Institute at the University of Edinburgh, Edinburgh, Scotland, UK.
Glia. 2025 Mar;73(3):619-631. doi: 10.1002/glia.24621. Epub 2024 Sep 23.
Astrocytes are a highly abundant cell type in the brain and spinal cord. Like neurons, astrocytes can be molecularly and functionally distinct to fulfill specialized roles. Recent technical advances in sequencing-based single cell assays have driven an explosion of omics data characterizing astrocytes in the healthy, aged, injured, and diseased central nervous system. In this review, we will discuss recent studies which have furthered our understanding of astrocyte biology and heterogeneity, as well as discuss the limitations and challenges of sequencing-based single cell and spatial genomics methods and their potential future utility.
星形胶质细胞是大脑和脊髓中数量极为丰富的一种细胞类型。与神经元一样，星形胶质细胞在分子和功能上也可能存在差异，以履行特定的职责。基于测序的单细胞分析技术的最新进展，推动了组学数据的激增，这些数据描绘了健康、衰老、损伤和患病中枢神经系统中的星形胶质细胞。在这篇综述中，我们将讨论最近的研究，这些研究加深了我们对星形胶质细胞生物学和异质性的理解，同时也讨论基于测序的单细胞和空间基因组学方法的局限性和挑战，以及它们未来潜在的用途。
