Kodama Sarah T, Khandpur Ria, Dunlap Jared, Smolen Julia, Keshishian Chris, O'Connell Kathleen A, Burkett Linda S, Siff Lauren N, Speich John E, Klausner Adam P
Department of Surgery/Division of Urology, Virginia Commonwealth University School of Medicine Richmond, VA, USA.
Department of Health and Behavior Studies, Columbia University New York, NY, USA.
Am J Clin Exp Urol. 2024 Aug 25;12(4):173-182. doi: 10.62347/ZZJF7946. eCollection 2024.
The objective of this study was to investigate the relationship between situational cues (running water, stress, cold, etc.) and overactive bladder (OAB) symptoms.
Women scheduled for urodynamic studies for clinical indications completed surveys to characterize OAB (ICIQ-OAB and OAB-V3) and responses to situational cues (validated long-form cues survey and a novel short-form cues survey). Participants were divided into two groups (Low-Bother urgency vs. High-Bother urgency), and OAB and cue survey responses were compared.
A total of 47 participants were enrolled in the study with 36 meeting inclusion criteria (15 Low-Bother and 21 High-Bother) with an overall mean age of 60.0 ± 10.0 years. The High-Bother urgency group scored significantly higher on multiple cue items in the long-form (P<0.05) and only "running water" in the short-form cues survey (P<0.05). In addition, "running water" was the only cue that was scored higher in both surveys (P<0.05).
This study showed that patients with High-Bother urgency may have increased symptom responses to environmental, mood, and cognitive cues. These findings suggest increased sensitivity to cues, especially "running water" in participants with bothersome OAB and the potential presence of a cue-specific OAB phenotype.
本研究的目的是调查情境线索（流水、压力、寒冷等）与膀胱过度活动症（OAB）症状之间的关系。
因临床指征计划进行尿动力学研究的女性完成了调查，以对OAB进行特征描述（ICIQ - OAB和OAB - V3）以及对情境线索的反应（经过验证的长格式线索调查和一项新的短格式线索调查）。参与者被分为两组（低困扰急迫性组与高困扰急迫性组），并比较了OAB和线索调查的反应。
共有47名参与者纳入研究，其中36名符合纳入标准（15名低困扰组和21名高困扰组），总体平均年龄为60.0±10.0岁。高困扰急迫性组在长格式调查中的多个线索项目上得分显著更高（P<0.05），在短格式线索调查中仅“流水”一项得分更高（P<0.05）。此外，“流水”是两项调查中唯一得分更高的线索（P<0.05）。
本研究表明，高困扰急迫性患者可能对环境、情绪和认知线索的症状反应增加。这些发现提示，对于困扰性OAB患者，尤其是对“流水”线索的敏感性增加，并且可能存在线索特异性的OAB表型。
