Kwon Whi-An, Kim Sung Han, Kim Sohee, Joung Jae Young, Chung Jinsoo, Lee Kang Hyun, Lee Sang-Jin, Seo Ho Kyung
Department of Urology, School of Medicine, Institute of Wonkwang Medical Science, Wonkwang University Sanbon Hospital, Gunpo, Gyeonggi-do, Korea.
Center for Prostate Cancer, National Cancer Center, Goyang, Korea.
PLoS One. 2015 May 15;10(5):e0126798. doi: 10.1371/journal.pone.0126798. eCollection 2015.
The sound of running water (SRW) has been effectively used for toilet training during toddlerhood. However, the effect of SRW on voiding functions in adult males with lower urinary tract symptoms (LUTS) has not been evaluated. To determine the effect of SRW on urination in male patients with LUTS, multiple voiding parameters of uroflowmetry with postvoid residual urine (PVR) were assessed according to the presence of SRW played by a mobile application.
Eighteen consecutive male patients with LUTS were prospectively enrolled between March and April 2014. Uroflowmetry with PVR measured by a bladder scan was randomly performed once weekly for two consecutive weeks with and without SRW in a completely sealed room after pre-checked bladder volume was scanned to be more than 150 cc. SRW was played with river water sounds amongst relaxed melodies from a smartphone mobile application.
The mean age of enrolled patients and their mean International Prostate Symptom Score (IPSS) were 58.9 ± 7.7 years (range: 46-70) and 13.1 ± 5.9, respectively. All patients had not been prescribed any medications, including alpha-blockers or anti-muscarinic agents, in the last 3 months. There was a significant increase in mean peak flow rate (PFR) with SRW in comparison to without SRW (15.7 mL/s vs. 12.3 mL/s, respectively, p = 0.0125). However, there were no differences in other uroflowmetric parameters, including PVR.
The study showed that SRW from a mobile phone application may be helpful in facilitating voiding functions by increasing PFR in male LUTS patients.
流水声（SRW）已被有效地用于幼儿期的如厕训练。然而，SRW对成年男性下尿路症状（LUTS）患者排尿功能的影响尚未得到评估。为了确定SRW对LUTS男性患者排尿的影响，根据移动应用程序播放的SRW的存在情况，评估了尿流率与排尿后残余尿量（PVR）的多个排尿参数。
2014年3月至4月前瞻性纳入了18例连续的LUTS男性患者。在预先检查膀胱容量扫描超过150 cc后，在一个完全密封的房间里，每周随机进行一次膀胱扫描测量PVR的尿流率，连续两周，分别在有和没有SRW的情况下进行。SRW是通过智能手机移动应用程序在轻松的旋律中播放河水声。
入选患者的平均年龄及其平均国际前列腺症状评分（IPSS）分别为58.9±7.7岁（范围：46 - 70岁）和13.1±5.9。所有患者在过去3个月内未服用任何药物，包括α受体阻滞剂或抗胆碱能药物。与没有SRW相比，有SRW时平均最大尿流率（PFR）显著增加（分别为15.7 mL/s和12.3 mL/s，p = 0.0125）。然而，其他尿流率参数，包括PVR，没有差异。
该研究表明，手机应用程序发出的SRW可能有助于通过增加LUTS男性患者的PFR来促进排尿功能。
