Hall Ashton D, Ferreri Joshua M, Baker Jennifer E, Powell Eleanor A, Ahmed Imran, Klostermeier Timothy T, Luckett Keith M
Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
IDCases. 2024 Sep 6;38:e02073. doi: 10.1016/j.idcr.2024.e02073. eCollection 2024.
Clostridial gas gangrene (CGG) is among the most rapidly spreading infections in humans, with mortality rates approaching 100 % if not treated promptly. Most cases follow traumatic inoculation, although spontaneous infections occur in a minority of patients with immunodeficiency. Spontaneous CGG is primarily caused by , whereas traumatic infection is associated with . Patients with CGG present abruptly with rapidly progressive symptoms, underscoring the importance of early recognition, prompt surgical intervention, and appropriate antimicrobial therapy. We describe an illustrative case of spontaneous CGG caused by in a polymorbid 73-year-old female patient. Despite aggressive medical and surgical management, she succumbed to metastatic infection within 48 h of presentation.
梭菌性气性坏疽（CGG）是人类中传播速度最快的感染之一，如果不及时治疗，死亡率接近100%。大多数病例是创伤性接种后发生的，不过少数免疫缺陷患者会出现自发性感染。自发性CGG主要由……引起，而创伤性感染与……有关。CGG患者症状突然出现且进展迅速，这凸显了早期识别、及时手术干预和适当抗菌治疗的重要性。我们描述了一例由……引起的自发性CGG的典型病例，患者为一名73岁的多病态女性。尽管采取了积极的药物和手术治疗措施，但她在就诊后48小时内死于转移性感染。
