Sugiura Yuki, Ono Fumiko, Nohara Masakatsu, Funabiki Mai, Kutara Kenji, Kanda Teppei, Yamada Etsuko, Horie Masanori
Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14, Hayashi-cho, Takamatsu, Kagawa, 761-0395, Japan.
Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1, Higashi, Tsukuba, Ibaragi, 305-3095, Japan.
Regen Ther. 2024 Sep 9;26:760-766. doi: 10.1016/j.reth.2024.08.021. eCollection 2024 Jun.
Rapid bone regeneration is crucial for restoring alveolar bone and oral functions following periodontal diseases. However, the development of effective biomedical materials for this purpose remains insufficient. While bone autografts can enhance bone regeneration, they are invasive to healthy areas. Specifically, for alveolar bone regeneration, the implanted material must possess adequate mechanical strength. Moreover, local administration is preferred for older adults, who are a primary target population, to maintain their quality of life. We developed a silica-substituted carbonate apatite (COAp-silica) block as newly bone substitute with a bone growth factor, featuring the major inorganic component of mature bone to enhance bone regeneration. COAp-silica block stimulated the bone remodeling process at the implantation site and demonstrated significantly better bone regeneration compared to currently used carbonate apatite substitutes. Therefore, this new material is expected to advance technologies for restoring occlusal function after periodontal disease.
快速骨再生对于牙周疾病后牙槽骨和口腔功能的恢复至关重要。然而，为此目的开发有效的生物医学材料仍然不足。虽然自体骨移植可以促进骨再生，但它们会侵入健康区域。具体而言，对于牙槽骨再生，植入材料必须具备足够的机械强度。此外，对于作为主要目标人群的老年人来说，局部给药更可取，以维持他们的生活质量。我们开发了一种含硅取代的碳酸磷灰石（COAp-二氧化硅）块体作为新型骨替代物，并结合骨生长因子，其主要无机成分与成熟骨相同，以促进骨再生。COAp-二氧化硅块体在植入部位刺激了骨重塑过程，与目前使用的碳酸磷灰石替代物相比，显示出明显更好的骨再生效果。因此，这种新材料有望推动牙周疾病后恢复咬合功能的技术发展。
