Du Rui, Liu Jie, Tang Xiaoyan, Chen Zili, Guan Lei, Gao WenHong, Huang Wei
Department of Ultrasound, General Hospital of Central Theater Command, No.627, Wuluo Road, Wuhan 430070, Hubei, China.
Department of Ultrasound, International Mongolian Hospital of Inner Mongolia, No. 83, University East Street, Hohhot 010020, Inner Mongolia, China.
Prev Med Rep. 2024 Sep 6;46:102877. doi: 10.1016/j.pmedr.2024.102877. eCollection 2024 Oct.
The α-klotho (αKl) is widely accepted as an anti-aging and anti-inflammatory protein. However, it is rarely reported on the function and mechanism of αKl in the overall population (including healthy people and those with history of chronic disease). The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are established as predictors of systemic inflammation. This study aims to investigate the relationship between NLR, PLR, and αKl levels in the overall population.
Data from 10,124 adults aged 40 years old and above, collected from NHANES 2007-2016, were analyzed. Associations between NLR, PLR, and αKl levels were assessed by weighted multivariate linear regression analyses, adjusting for potential confounders. Subgroup analysis was conducted by gender, age, diabetes, cardiovascular disease, and chronic kidney disease.
Weighted linear regression models showed that a significant negative correlation was observed between both NLR and PLR with αKl levels. Subgroup analysis revealed that the negative correlation between NLR and serum αKl levels was not significant in individuals aged 40-59 years and males, while this relationship remained stable across most other subgroups. The negative correlation between PLR and serum αKl levels was consistent across most subgroups but not significant in individuals with cardiovascular disease.
Our study revealed a significant negative relationship between inflammatory markers (NLR and PLR) and serum αKl levels, suggesting systemic inflammation may be linked to reduced αKl expression. Subgroup analyses showed that the relationship varies across different demographic and health-related factors. We provided insight into the significance of managing inflammation and preserving αKl levels.
α-klotho（αKl）被广泛认为是一种抗衰老和抗炎蛋白。然而，关于αKl在总体人群（包括健康人群和有慢性病病史的人群）中的功能和机制鲜有报道。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）已被确立为全身炎症的预测指标。本研究旨在探讨总体人群中NLR、PLR与αKl水平之间的关系。
分析了2007 - 2016年美国国家健康与营养检查调查（NHANES）收集的10124名40岁及以上成年人的数据。通过加权多元线性回归分析评估NLR、PLR与αKl水平之间的关联，并对潜在混杂因素进行校正。按性别、年龄、糖尿病、心血管疾病和慢性肾脏病进行亚组分析。
加权线性回归模型显示，NLR和PLR与αKl水平均呈显著负相关。亚组分析显示，NLR与血清αKl水平之间的负相关在40 - 59岁个体和男性中不显著，而在大多数其他亚组中这种关系保持稳定。PLR与血清αKl水平之间的负相关在大多数亚组中一致，但在心血管疾病患者中不显著。
我们的研究揭示了炎症标志物（NLR和PLR）与血清αKl水平之间存在显著负相关，提示全身炎症可能与αKl表达降低有关。亚组分析表明，这种关系因不同的人口统计学和健康相关因素而异。我们深入了解了控制炎症和维持αKl水平的重要性。
