Song Ji-Eun, Hwang Ji-In, Ko Hae-Jin, Park Ji-Yeon, Hong Hee-Eun, Kim A-Sol
Department of Family Medicine, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.
Department of Family Medicine, Kyungpook National University Hospital, Daegu 41944, Republic of Korea.
J Cardiovasc Dev Dis. 2024 Feb 21;11(3):73. doi: 10.3390/jcdd11030073.
This study investigated the association between atherosclerosis and systemic inflammation markers, specifically the C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in healthy middle-aged adults.
A retrospective cross-sectional study was conducted on a total of 1264 Korean adults aged 40-65. We assessed these inflammatory markers and carotid metrics, such as carotid intima-media thickness (cIMT), plaque number (PN), plaque stenosis score (PSS), and plaque score (PS), using linear regression, logistic regression, and receiver operating characteristic analysis.
In males, the ESR and CRP were significantly correlated with the PN ( < 0.001 and = 0.048, respectively). The ESR was correlated with the PN in females ( = 0.004). The NLR and PLR both correlated with the PS in males ( < 0.001 and = 0.015, respectively) and females ( = 0.015 and = 0.023, respectively). The odds ratio for the NLR as a risk factor for increased cIMT was 1.15 (95% confidence interval [CI], 1.03-2.15) for males and 1.05 (95% CI, 1.01-1.29) for females. The AUC for the NLR and PLR as a predictor for the PS showed significance in both men and women.
Inflammatory markers, particularly the NLR and PLR, demonstrate a correlation with carotid atherosclerosis. Both the NLR and PLR hold potential as valuable surrogate markers for carotid atherosclerosis. To further substantiate their predictive efficacy, further prospective studies are needed.
本研究调查了健康中年成年人中动脉粥样硬化与全身炎症标志物之间的关联，具体为C反应蛋白（CRP）、红细胞沉降率（ESR）、中性粒细胞与淋巴细胞比值（NLR）以及血小板与淋巴细胞比值（PLR）。
对1264名年龄在40 - 65岁的韩国成年人进行了一项回顾性横断面研究。我们使用线性回归、逻辑回归和受试者工作特征分析评估了这些炎症标志物以及颈动脉指标，如颈动脉内膜中层厚度（cIMT）、斑块数量（PN）、斑块狭窄评分（PSS）和斑块评分（PS）。
在男性中，ESR和CRP与PN显著相关（分别为<0.001和 = 0.048）。女性中ESR与PN相关（ = 0.004）。NLR和PLR在男性（分别为<0.001和 = 0.015）和女性（分别为 = 0.015和 = 0.023）中均与PS相关。NLR作为cIMT增加的危险因素，男性的比值比为1.15（95%置信区间[CI]，1.03 - 2.15），女性为1.05（95%CI，1.01 - 1.29）。NLR和PLR作为PS预测指标的曲线下面积在男性和女性中均具有显著性。
炎症标志物，尤其是NLR和PLR，与颈动脉粥样硬化存在相关性。NLR和PLR都有潜力作为颈动脉粥样硬化的有价值替代标志物。为进一步证实它们的预测效力，需要进一步的前瞻性研究。
