Xiang Aiqun, Peng Zixuan, He Hong, Meng Xuyun, Luo Yanting, Yang Junming, Zeng Fang, Chen Xiaolian, Zhong Xingwu
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, China.
Heliyon. 2024 Sep 4;10(18):e37416. doi: 10.1016/j.heliyon.2024.e37416. eCollection 2024 Sep 30.
Drug treatment studies are a focal point for identifying novel approaches to reduce myopia progression through basic science research. Here, we investigated the effects of various brimonidine administration routes and concentrations on form-deprivation myopia (FDM) progression, matrix metalloproteinase-2 (MMP-2), and collagen alpha1 chain of type I (COL1A1) expression in the retinal pigment epithelial (RPE)-choroid complex and sclera of guinea pigs. They demonstrate that brimonidine has the capacity to impede choroidal thinning induced by FDM, potentially through the induction of choroidal vasodilation. Additionally, we observed that brimonidine effectively counteracts FDM-induced downregulation of choroidal and scleral MMP-2 expression. Suppression of MMP-2 expression may reduce disruption of scleral and choroidal structural integrity which reduces declines in choroidal blood circulation and mitigates increases in ocular elongation. This research elucidates the effects of brimonidine on myopia progression, offering potential insights into therapeutic interventions for myopia.
药物治疗研究是通过基础科学研究确定减少近视进展新方法的一个焦点。在此，我们研究了不同给药途径和浓度的溴莫尼定对豚鼠视网膜色素上皮（RPE）-脉络膜复合体和巩膜中形觉剥夺性近视（FDM）进展、基质金属蛋白酶-2（MMP-2）以及I型胶原α1链（COL1A1）表达的影响。研究表明，溴莫尼定有能力阻止FDM诱导的脉络膜变薄，可能是通过诱导脉络膜血管舒张来实现的。此外，我们观察到溴莫尼定能有效对抗FDM诱导的脉络膜和巩膜MMP-2表达下调。MMP-2表达的抑制可能会减少巩膜和脉络膜结构完整性的破坏，从而减少脉络膜血液循环的下降并减轻眼轴伸长的增加。这项研究阐明了溴莫尼定对近视进展的影响，为近视的治疗干预提供了潜在的见解。
