Wang Bangchen, Schub Micah, Ortiz-Melo David I, Barisoni Laura
Department of Pathology, Duke University Health Systems, Durham, NC.
Division of Nephrology, Department of Medicine, Duke University Health Systems, Durham, NC.
Kidney Med. 2024 Aug 10;6(10):100887. doi: 10.1016/j.xkme.2024.100887. eCollection 2024 Oct.
Paraneoplastic cast nephropathy, a rare cause of acute kidney injury, is most commonly observed in cases of multiple myeloma and is characterized by the formation of intratubular casts composed of monoclonal light chains. Nonmonoclonal paraneoplastic cast nephropathy has also been reported in patients with pancreatic acinar cell carcinoma or prolactinoma. In this case report, we present a case of polyclonal cast nephropathy in a patient with metastatic acinar cell carcinoma. We aim to emphasize the significance of recognizing this uncommon complication in patients with solid tumors and to discuss the diagnostic challenges and potential pathophysiology of this unique condition.
副肿瘤性管型肾病是急性肾损伤的一种罕见病因，最常见于多发性骨髓瘤患者，其特征是形成由单克隆轻链组成的肾小管内管型。非单克隆副肿瘤性管型肾病也在胰腺腺泡细胞癌或泌乳素瘤患者中有所报道。在本病例报告中，我们呈现了一例转移性腺泡细胞癌患者发生多克隆管型肾病的病例。我们旨在强调认识实体瘤患者中这种罕见并发症的重要性，并讨论这一独特病症的诊断挑战和潜在病理生理学。
