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A Comprehensive Review of the Role of Stem Cells in Neuroregeneration: Potential Therapies for Neurological Disorders.

作者信息

Deokate Navanath, Acharya Sourya, Patil Rajvardhan, Shaikh Suhail M, Karwa Vineet

机构信息

Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, IND.

出版信息

Cureus. 2024 Aug 22;16(8):e67506. doi: 10.7759/cureus.67506. eCollection 2024 Aug.


DOI:10.7759/cureus.67506
PMID:39310492
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11416137/
Abstract

Stem cell research has emerged as a groundbreaking field with significant potential for advancing neuroregeneration and neurological disorder treatment. Neurological conditions such as Alzheimer's disease, Parkinson's disease, stroke, and spinal cord injuries pose severe challenges due to their impact on quality of life and the limited efficacy of current treatments, which primarily focus on symptom management rather than addressing the underlying damage. Neuroregeneration, the process of repairing and restoring damaged neural tissues, is crucial for improving patient outcomes, given the central nervous system's limited intrinsic repair capacity. Stem cells offer a promising solution due to their ability to self-renew and differentiate into various neural cell types, providing opportunities for innovative therapies. This review provides a comprehensive analysis of the role of stem cells in neuroregeneration, exploring different types of stem cells, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and adult stem cells, and their mechanisms of action in neural repair. It examines current clinical trials and translational research efforts, highlighting successes and ongoing challenges such as ethical considerations, immunogenicity, and technical limitations. The review also discusses future directions in stem cell research, including advancements in gene editing, tissue engineering, and personalized medicine. By addressing these aspects, the review aims to offer a thorough understanding of the potential and challenges of stem cell-based therapies, contributing to the development of effective treatments for neurological disorders and ultimately enhancing patient quality of life.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a2/11416137/80deb72cac24/cureus-0016-00000067506-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a2/11416137/80deb72cac24/cureus-0016-00000067506-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a2/11416137/80deb72cac24/cureus-0016-00000067506-i01.jpg

相似文献

[1]
A Comprehensive Review of the Role of Stem Cells in Neuroregeneration: Potential Therapies for Neurological Disorders.

Cureus. 2024-8-22

[2]
Stem cell therapies for neurological disorders: current progress, challenges, and future perspectives.

Eur J Med Res. 2024-7-25

[3]
Advancing Spinal Cord Injury Treatment through Stem Cell Therapy: A Comprehensive Review of Cell Types, Challenges, and Emerging Technologies in Regenerative Medicine.

Int J Mol Sci. 2023-9-20

[4]
Neuronal Cell Differentiation of iPSCs for the Clinical Treatment of Neurological Diseases.

Biomedicines. 2024-6-18

[5]
Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and Limitations.

Curr Stem Cell Res Ther. 2020

[6]
Human Pluripotent Stem Cells for Spinal Cord Injury.

Curr Stem Cell Res Ther. 2020

[7]
Stem cell-based combinatorial therapies for spinal cord injury: a narrative review of current research and future directions.

Ann Med Surg (Lond). 2023-7-3

[8]
Therapeutic Potential of Human Amniotic Epithelial Cells on Injuries and Disorders in the Central Nervous System.

Stem Cells Int. 2019-11-20

[9]
Directing Induced Pluripotent Stem Cell Derived Neural Stem Cell Fate with a Three-Dimensional Biomimetic Hydrogel for Spinal Cord Injury Repair.

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[10]
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引用本文的文献

[1]
Neural stem cells in adult neurogenesis and their therapeutic applications in neurodegenerative disorders: a concise review.

Front Mol Med. 2025-6-19

[2]
Stem cell repair strategies for epilepsy.

Neural Regen Res. 2026-4-1

[3]
Advances in the Research of Mesenchymal Stromal Cells in the Treatment of Maxillofacial Neurological Disorders and the Promotion of Facial Nerve Regeneration.

Mol Neurobiol. 2025-4-28

本文引用的文献

[1]
Recent Therapeutic Gene Editing Applications to Genetic Disorders.

Curr Issues Mol Biol. 2024-4-30

[2]
CRISPR Advancements for Human Health.

Mo Med. 2024

[3]
Application of CRISPR-Cas9 genome editing technology in various fields: A review.

Narra J. 2023-8

[4]
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy.

Mol Cancer. 2023-11-28

[5]
Advancing Spinal Cord Injury Treatment through Stem Cell Therapy: A Comprehensive Review of Cell Types, Challenges, and Emerging Technologies in Regenerative Medicine.

Int J Mol Sci. 2023-9-20

[6]
Stem cell-based combinatorial therapies for spinal cord injury: a narrative review of current research and future directions.

Ann Med Surg (Lond). 2023-7-3

[7]
Differentiation of neurosphere after transplantation into the damaged spinal cord.

J Med Life. 2023-5

[8]
Assessing Tumorigenicity in Stem Cell-Derived Therapeutic Products: A Critical Step in Safeguarding Regenerative Medicine.

Bioengineering (Basel). 2023-7-19

[9]
Neuronal regeneration after injury: a new perspective on gene therapy.

Front Neurosci. 2023-4-21

[10]
Advancing cell therapy for neurodegenerative diseases.

Cell Stem Cell. 2023-5-4

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