• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在度普利尤单抗治疗特应性皮炎期间停用外用皮质类固醇后传染性软疣消退：一例报告

Resolution of Molluscum Contagiosum After Discontinuation of Topical Corticosteroids During Dupilumab Therapy for Atopic Dermatitis: A Case Report.

作者信息

Yunoki Marina, Fukuchi Kensuke, Fujiyama Toshiharu, Ito Taisuke, Honda Tetsuya

机构信息

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, JPN.

出版信息

Cureus. 2024 Aug 21;16(8):e67391. doi: 10.7759/cureus.67391. eCollection 2024 Aug.

DOI:10.7759/cureus.67391
PMID:39310604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11415223/
Abstract

A 35-year-old male patient with atopic dermatitis (AD) was referred to our department for exacerbated AD lesions. His sudden discontinuation of topical corticosteroid had induced erythroderma on his face, extremities, and trunk. Additionally, he presented small multiple whitish papules, mainly on the trunk and thighs, diagnosed as molluscum contagiosum (MC). Dupilumab was initiated in combination with a topical corticosteroid (0.05% betamethasone butyrate propionate). After four weeks, the AD symptoms substantially improved, while MC showed no changes. After 11 weeks of dupilumab therapy, he abruptly stopped topical corticosteroid treatment, and the MC lesions completely resolved in two weeks.

摘要

一名35岁的特应性皮炎（AD）男性患者因AD皮损加重被转诊至我科。他突然停用外用糖皮质激素后，面部、四肢和躯干出现了红皮病。此外，他躯干和大腿上出现了多个小的白色丘疹，诊断为传染性软疣（MC）。开始使用度普利尤单抗联合外用糖皮质激素（0.05%丙酸倍他米松丁酸酯）治疗。四周后，AD症状显著改善，而MC无变化。度普利尤单抗治疗11周后，他突然停止外用糖皮质激素治疗，MC皮损在两周内完全消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c4c/11415223/2ff5f5954a4a/cureus-0016-00000067391-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c4c/11415223/eb32c26e9b21/cureus-0016-00000067391-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c4c/11415223/73415094cebb/cureus-0016-00000067391-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c4c/11415223/2ff5f5954a4a/cureus-0016-00000067391-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c4c/11415223/eb32c26e9b21/cureus-0016-00000067391-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c4c/11415223/73415094cebb/cureus-0016-00000067391-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c4c/11415223/2ff5f5954a4a/cureus-0016-00000067391-i03.jpg

相似文献

1
Resolution of Molluscum Contagiosum After Discontinuation of Topical Corticosteroids During Dupilumab Therapy for Atopic Dermatitis: A Case Report.在度普利尤单抗治疗特应性皮炎期间停用外用皮质类固醇后传染性软疣消退：一例报告
Cureus. 2024 Aug 21;16(8):e67391. doi: 10.7759/cureus.67391. eCollection 2024 Aug.
2
Clinical remission of disseminated molluscum contagiosum infection in a patient with atopic dermatitis treated with dupilumab.阿特 氏皮炎患者接受度普利尤单抗治疗后，播散性传染性软疣感染临床缓解。
An Bras Dermatol. 2022 May-Jun;97(3):358-361. doi: 10.1016/j.abd.2021.10.001. Epub 2022 Mar 17.
3
Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.获得性免疫缺陷综合征患者巨大传染性软疣的皮肤镜特征
Acta Dermatovenerol Croat. 2020 Dec;28(7):233-235.
4
Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial.度普利尤单抗联合外用皮质类固醇治疗中重度特应性皮炎的长期管理（LIBERTY AD CHRONOS）：一项为期 1 年、随机、双盲、安慰剂对照、3 期临床试验。
Lancet. 2017 Jun 10;389(10086):2287-2303. doi: 10.1016/S0140-6736(17)31191-1. Epub 2017 May 4.
5
Experience with molluscum contagiosum and associated inflammatory reactions in a pediatric dermatology practice: the bump that rashes.小儿皮肤科诊所中传染性软疣及相关炎症反应的经验：引发皮疹的肿块
Arch Dermatol. 2012 Nov;148(11):1257-64. doi: 10.1001/archdermatol.2012.2414.
6
Erythrodermic Presentation of Atopic Dermatitis in a Patient with Secondary Adrenal Insufficiency Caused by Oral Glucocorticosteroid Abuse.因滥用口服糖皮质激素导致的继发性肾上腺功能不全的特应性皮炎患者出现红皮病表现。
Acta Dermatovenerol Croat. 2023 Nov;31(2):103-105.
7
Berdazimer gel for molluscum contagiosum in patients with atopic dermatitis.苯扎氯铵凝胶治疗特应性皮炎患者的传染性软疣。
Pediatr Dermatol. 2024 May-Jun;41(3):438-444. doi: 10.1111/pde.15575. Epub 2024 Feb 27.
8
No Increased Risk of Overall Infection in Adults with Moderate-to-Severe Atopic Dermatitis Treated for up to 4 Years with Dupilumab.在长达 4 年的时间里，接受度普利尤单抗治疗的中重度特应性皮炎成人患者的总体感染风险没有增加。
Adv Ther. 2023 Jan;40(1):367-380. doi: 10.1007/s12325-022-02322-y. Epub 2022 Nov 1.
9
Molluscum contagiosum surrounded by a white halo and Sezary syndrome.传染性软疣，周围有白色晕圈和蕈样肉芽肿。
J Eur Acad Dermatol Venereol. 2015 Sep;29(9):1837-9. doi: 10.1111/jdv.12694. Epub 2014 Sep 3.
10
Laboratory Safety from a Randomized 16-Week Phase III Study of Dupilumab in Children Aged 6 Months to 5 Years with Moderate-to-Severe Atopic Dermatitis.一项为期 16 周的随机 III 期研究：度普利尤单抗对 6 个月至 5 岁中重度特应性皮炎儿童的实验室安全性。
Paediatr Drugs. 2023 Jan;25(1):67-77. doi: 10.1007/s40272-022-00553-8. Epub 2022 Dec 19.

引用本文的文献

1
with atopic dermatitis: a clinical retrospective study of 2,278 children.特应性皮炎：2278例儿童的临床回顾性研究
Front Pediatr. 2025 Jul 7;13:1543309. doi: 10.3389/fped.2025.1543309. eCollection 2025.

本文引用的文献

1
Molluscum Contagiosum: Epidemiology, Considerations, Treatment Options, and Therapeutic Gaps.传染性软疣：流行病学、注意事项、治疗选择及治疗差距
J Clin Aesthet Dermatol. 2023 Aug;16(8 Suppl 1):S4-S11.
2
Clinical remission of disseminated molluscum contagiosum infection in a patient with atopic dermatitis treated with dupilumab.阿特 氏皮炎患者接受度普利尤单抗治疗后，播散性传染性软疣感染临床缓解。
An Bras Dermatol. 2022 May-Jun;97(3):358-361. doi: 10.1016/j.abd.2021.10.001. Epub 2022 Mar 17.
3
Dupilumab may facilitate the clearance of molluscum contagiosum in atopic dermatitis patients.
度普利尤单抗可能有助于特应性皮炎患者清除传染性软疣。
J Dtsch Dermatol Ges. 2020 Sep;18(9):1016-1018. doi: 10.1111/ddg.14257. Epub 2020 Sep 2.
4
Transitory Dissemination of Molluscum Contagiosum in a Patient Treated with Dupilumab for Atopic Dermatitis.用度普利尤单抗治疗特应性皮炎患者时传染性软疣的短暂播散
Acta Derm Venereol. 2020 Jul 2;100(14):adv00207. doi: 10.2340/00015555-3565.
5
Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment.传染性软疣：病因、诊断及治疗新视角的最新进展与综述
Clin Cosmet Investig Dermatol. 2019 May 30;12:373-381. doi: 10.2147/CCID.S187224. eCollection 2019.
6
Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis.特应性皮炎度普利尤单抗临床试验中的感染：综合汇总分析。
Am J Clin Dermatol. 2019 Jun;20(3):443-456. doi: 10.1007/s40257-019-00445-7.
7
Hair regrowth and dissemination of molluscum contagiosum: two unexpected effects with dupilumab.毛发再生与传染性软疣扩散：度普利尤单抗的两种意外效应
J Eur Acad Dermatol Venereol. 2019 Aug;33(8):e296-e298. doi: 10.1111/jdv.15571. Epub 2019 Mar 29.
8
Clearance of molluscum contagiosum virus infection in patients with atopic eczema treated with dupilumab.使用度普利尤单抗治疗的特应性皮炎患者传染性软疣病毒感染的清除情况。
Br J Dermatol. 2019 Aug;181(2):385-386. doi: 10.1111/bjd.17712. Epub 2019 Apr 19.
9
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis.度普利尤单抗治疗中重度特应性皮炎成人患者。
N Engl J Med. 2014 Jul 10;371(2):130-9. doi: 10.1056/NEJMoa1314768.