Li Tingying, Gao Nan, Zeng Zilu, Fu Guili
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Front Pediatr. 2025 Jul 7;13:1543309. doi: 10.3389/fped.2025.1543309. eCollection 2025.
The dissemination of (MC), a prevalent pediatric cutaneous viral infection, is enhanced upon atopic dermatitis (AD) or compromised epidermal barrier function. However, the potential influence of AD on the course of MC remains controversial. This study aimed to evaluate the influence of AD on MC treatment outcomes.
In this clinical retrospective study, we enrolled children with MC and divided them into control (patients with MC alone) and observation (patients with both MC and AD) groups. Parameters such as sex, age, treatment sessions, and treatment duration were recorded for all patients. Efficacy endpoints were defined as complete clearance, with no further MC treatment required for half a year. Chi-squared and -tests were performed to compare the clinical and demographic parameters between the groups.
Among 2,278 patients, 1,931 (84.77%) had MC alone, and 347 (15.23%) had concurrent MC and AD. Significant differences were observed in treatment sessions ( < 0.05) between the two groups. However, sex, age, and treatment duration did not differ significantly between the groups ( > 0.05).
AD increased the number of treatment sessions of MC in children but was not closely related to sex, age, or treatment duration.
传染性软疣（MC）是一种常见的儿童皮肤病毒感染，在特应性皮炎（AD）或表皮屏障功能受损时其传播会增强。然而，AD对MC病程的潜在影响仍存在争议。本研究旨在评估AD对MC治疗结果的影响。
在这项临床回顾性研究中，我们纳入了患有MC的儿童，并将他们分为对照组（仅患有MC的患者）和观察组（同时患有MC和AD的患者）。记录了所有患者的性别、年龄、治疗次数和治疗持续时间等参数。疗效终点定义为完全清除，半年内无需进一步进行MC治疗。进行卡方检验和t检验以比较两组之间的临床和人口统计学参数。
在2278例患者中，1931例（84.77%）仅患有MC，347例（15.23%）同时患有MC和AD。两组之间在治疗次数上观察到显著差异（P<0.05）。然而，两组之间的性别、年龄和治疗持续时间没有显著差异（P>0.05）。
AD增加了儿童MC的治疗次数，但与性别、年龄或治疗持续时间没有密切关系。
