Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
Acta Clin Croat. 2023 Nov;62(3):415-425. doi: 10.20471/acc.2023.62.03.3.
The purpose of this study was to examine the possible association between cheilitis and allergic reactions, and to use allergy skin tests to identify the allergens that induce allergic reactions in cheilitis patients (type I and type IV). We included 50 patients with recurrent cheilitis (reversible cheilitis) who were dermatologically examined and agreed to undergo allergy skin tests, i.e., patch test and prick test. Additionally, clinical pictures and patient mental stress levels were examined using the Perceived Stress Scale (PSS). Positive prick tests (atopy) were recorded in 84% of patients with cheilitis. The most frequently found allergens were contact allergens (54%) (cobalt chloride, nickel sulfate and thimerosal) and inhalant allergens (46%). The patch test positive subjects who used cosmetic, hygiene, and decorative products were significantly more likely to have swollen and red lips than the patch test negative subjects. Also, low stress levels were recorded less frequently in patients with confirmed allergies than in non-allergic patients. The results indicated a higher incidence of cheilitis in the people prone to allergies (atopics) and confirmed an association between cheilitis and allergies. To our knowledge, this is the first study in patients with cheilitis, which simultaneously analyzed allergies, their clinical features and PSS in the same patients.
本研究旨在探讨唇炎与过敏反应之间可能存在的关联，并通过过敏皮肤测试来确定引起唇炎患者（I 型和 IV 型）过敏反应的过敏原。我们纳入了 50 例复发性唇炎（可逆性唇炎）患者，对他们进行了皮肤科检查，并同意进行过敏皮肤测试，即斑贴试验和皮内试验。此外，还使用感知压力量表（PSS）检查了临床图片和患者的精神压力水平。唇炎患者中有 84%存在阳性皮内试验（特应性）。最常见的过敏原是接触性过敏原（54%）（氯化钴、硫酸镍和硫柳汞）和吸入性过敏原（46%）。使用化妆品、卫生和装饰产品的斑贴试验阳性者比斑贴试验阴性者更有可能出现嘴唇肿胀和发红。而且，在有确诊过敏的患者中，压力水平低的情况也较少见。结果表明，过敏体质（特应性）的人唇炎发病率更高，并证实了唇炎与过敏之间的关联。据我们所知，这是首例在唇炎患者中同时分析过敏、其临床特征和 PSS 的研究。
