Gallivan M V, Chun B, Rowden G, Lack E E
Am J Surg Pathol. 1979 Feb;3(1):85-92. doi: 10.1097/00000478-197902000-00010.
Laryngeal paraganglioma is an infrequently reported tumor; only 16 examples have been recorded in the English literature. All but one laryngeal paraganglioma originated superiorly in the larynx; involvement of the ipsilateral aryepiglottic fold is common. Male patients predominate (11:5). The average age of patients at the time of diagnosis was 47 years, and symptoms had been present for an average duration of 5.8 years (range 6 months to 27 years). Attempted biopsy has resulted in significant hemorrhage in three cases. As illustrated by the present case, the Grimelius argyrophil stain is a useful diagnostic procedure. Electron microscopy confirmed the presence of neurosecretory granules with core diameters ranging from 110 to 140 nm. Surgical resection is the preferred treatment and has been possible in 14 cases; nine patients are alive and free of tumor for an average of 3 years. Compared to other head and neck paragangliomas, these have a more malignant course with a 25% mortality; tender subcutaneous metastases are commonly observed in these patients.
喉副神经节瘤是一种报道较少的肿瘤；英文文献中仅记录了16例。除1例喉副神经节瘤起源于喉下部外，其余均起源于喉上部；同侧杓会厌襞受累很常见。男性患者居多（11例男性对5例女性）。患者诊断时的平均年龄为47岁，症状出现的平均持续时间为5.8年（范围为6个月至27年）。3例患者在尝试活检时出现大量出血。如本病例所示， Grimelius嗜银染色是一种有用的诊断方法。电子显微镜证实存在核心直径为110至140纳米的神经分泌颗粒。手术切除是首选治疗方法，14例患者已成功进行手术；9例患者存活且无肿瘤，平均时间为3年。与其他头颈部副神经节瘤相比，这些肿瘤的病程更具侵袭性，死亡率为25%；这些患者常出现皮下转移性肿块并有压痛。
