Sneige N, Mackay B, Ordonez N G, Batsakis J G
Arch Otolaryngol. 1983 Feb;109(2):113-7. doi: 10.1001/archotol.1983.00800160047012.
Paraganglionic tumors of the larynx are uncommon neoplasms and their secretory products have rarely been elucidated. We saw two patients whose laryngeal paragangliomas were examined with an electron microscope and by the use of immunocytochemical techniques. Both tumors manifested positive immunoreactivity against calcitonin and vasoactive intestinal polypeptide. One of the paragangliomas was immunoreactive against carcinoembryonic antigen and pursued a biologically malignant course. Our observations suggest the coexistence of amines and hormonal polypeptides in cells of paraganglionic tumors and demonstrate the multihormonal nature of these tumors.
喉副神经节瘤是一种罕见的肿瘤，其分泌产物鲜有阐明。我们诊治了两名患者，对其喉部副神经节瘤进行了电子显微镜检查和免疫细胞化学技术检测。两个肿瘤对降钙素和血管活性肠多肽均表现出阳性免疫反应。其中一个副神经节瘤对癌胚抗原有免疫反应，并呈生物学恶性病程。我们的观察结果提示副神经节瘤细胞中胺类和激素多肽共存，并证实了这些肿瘤的多激素性质。
