Spagnolo D V, Paradinas F J
Histopathology. 1985 Jan;9(1):117-31. doi: 10.1111/j.1365-2559.1985.tb02975.x.
A supraglottic laryngeal neuroendocrine tumour in a 71-year-old female is presented. In addition to the typical features of extra-adrenal paragangliomas it showed unusual, numerous intracytoplasmic lumina and occasional true acini with accumulation of alcian blue and PAS positive secretory product in them which led originally to an erroneous diagnosis of metastatic adenocarcinoma. Ultrastructurally, the tumour was composed of light and dark chief cells containing varying numbers of dense-core secretory granules. Intracytoplasmic lumina and true acini contained microvilli with glycocalyceal material and varying amounts of membranous and amorphous material, possibly secreted via small, smooth-surfaced cytoplasmic vesicles but typical mucin granules were not seen. These features have not been previously described in laryngeal paragangliomas but are seen in endocrine tumours of other sites and have been used as an argument in favour of an endodermal rather than ectodermal origin for endocrine cells in those sites. Laryngeal paragangliomas are often malignant and the presence of spasmodic pain appears to be the most reliable indication of possible malignancy, histological criteria being as yet poorly defined.
本文报告了一名71岁女性的声门上喉神经内分泌肿瘤。除了具有肾上腺外副神经节瘤的典型特征外，该肿瘤还表现出不寻常的大量胞质内管腔，以及偶尔出现的真正腺泡，其中积聚了阿尔辛蓝和PAS阳性分泌产物，这最初导致误诊为转移性腺癌。超微结构上，肿瘤由含有不同数量致密核心分泌颗粒的亮细胞和暗细胞组成。胞质内管腔和真正的腺泡含有带有糖萼物质的微绒毛以及不同数量的膜性和无定形物质，这些物质可能通过小的、表面光滑的细胞质囊泡分泌，但未见到典型的粘蛋白颗粒。这些特征以前在喉副神经节瘤中未被描述过，但在其他部位的内分泌肿瘤中可见，并且被用作支持这些部位内分泌细胞起源于内胚层而非外胚层的论据。喉副神经节瘤通常是恶性的，痉挛性疼痛的出现似乎是可能恶性的最可靠指标，组织学标准尚不明确。
