Department of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.
Institute of Hypertension, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.
J Clin Hypertens (Greenwich). 2024 Nov;26(11):1256-1263. doi: 10.1111/jch.14906. Epub 2024 Sep 23.
The association of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) with insulin resistance (IR), as measured by homeostasis model assessment of insulin resistance (HOMA-IR), in the general population is unclear. Our study aimed to characterize its relationship in a large community-based population. Subjects were recruited from the Danyang city between 2017 and 2019. Serum NT-proBNP was measured using an enhanced chemiluminescence immunoassay. IR was defined by a HOMA-IR in the highest sex-specific quartile. Categorical and continuous analyses were performed with sex-specific NT-proBNP tertiles and naturally logarithmically transformed NT-proBNP (lnNTproBNP), respectively. The 2945 participants (mean age 52.8 years) included 1728 (58.7%) women, 1167 (39.6%) hypertensive patients, 269 (9.1%) diabetic patients, and 736 (25.0%) patients with IR. In simple and multivariate-adjusted regression analyses, serum lnNTproBNP were both negatively associated with HOMA-IR (β = -0.19 to -0.25; p < 0.0001). Similar results were also obtained in multiple subgroup analyses. In multiple logistic regression analyses, elevated serum NT-proBNP was associated with lower risks of IR (odds ratios: 0.68 and 0.39; 95% confidence intervals: 0.61-0.74 and 0.30-0.50 for lnNTproBNP and top vs. bottom tertiles, respectively; p < 0.0001). In conclusion, increased serum NT-proBNP level was strongly associated with a lower risk of IR in Chinese.
血清 N 末端脑利钠肽前体（NT-proBNP）与胰岛素抵抗（IR）的相关性，以胰岛素抵抗评估的稳态模型（HOMA-IR）来衡量，在一般人群中尚不清楚。我们的研究旨在描述其在大型社区人群中的关系。研究对象于 2017 年至 2019 年期间从丹阳市招募。使用增强化学发光免疫测定法测量血清 NT-proBNP。IR 通过最高性别特异性四分位数的 HOMA-IR 定义。使用性别特异性 NT-proBNP 三分位和自然对数转换的 NT-proBNP（lnNTproBNP）分别进行分类和连续分析。2945 名参与者（平均年龄 52.8 岁）包括 1728 名（58.7%）女性、1167 名（39.6%）高血压患者、269 名（9.1%）糖尿病患者和 736 名（25.0%）IR 患者。在简单和多元调整回归分析中，血清 lnNTproBNP 均与 HOMA-IR 呈负相关（β=-0.19 至-0.25；p<0.0001）。在多个亚组分析中也得到了类似的结果。在多元逻辑回归分析中，升高的血清 NT-proBNP 与较低的 IR 风险相关（比值比：0.68 和 0.39；95%置信区间：lnNTproBNP 和顶部与底部三分位相比，分别为 0.61-0.74 和 0.30-0.50；p<0.0001）。总之，在中国人群中，血清 NT-proBNP 水平升高与 IR 风险降低密切相关。
