Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China.
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University and Capital Medical University, Beijing, China.
Medicine (Baltimore). 2024 Sep 20;103(38):e39675. doi: 10.1097/MD.0000000000039675.
The aim of this study is to explore the traditional Chinese medicine (TCM) constitution among individuals suffering from dry eye disease. Following the diagnostic criteria outlined in TFO DEWS II, a total of 114 patients with dry eye were included in this study. Based on the classification criteria for dry eye, the patients were categorized into 3 distinct dry eye subtypes. Each participant underwent a thorough clinical assessment for dry eye, and their TCM pattern manifestations were assessed using the "Traditional Chinese Medicine Questionnaire for Dry Eye." The Nine Constitutions Assessment Method was utilized for TCM pattern differentiation and classification. Spearman's correlation analysis was employed to investigate the associations between TCM constitution and dry eye subtypes, clinical indicators, and the relationships between TCM syndromes and dry eye subtypes. Among the 114 patients, the Qi-Stagnation constitution was the most common, with variations in constitution distribution among different dry eye subtypes. Significant correlations were observed between the Blood-Stasis, Yin-Deficiency, Qi-Deficiency, and Yang-Deficiency constitutions and 2, 4, 1, and 4 dry eye indicators, respectively. Spearman's analysis revealed that 5 out of 50 TCM syndromes were associated with mixed dry eye, 5 with evaporative dry eye, and 3 with aqueous tear deficiency dry eye. Further analysis, using lasso regression and binary unconditional logistic regression identified dizziness, lumbago, and weakness as influencing factors for both mixed-type and evaporative-type dry eye. In this study, we extensively examined the TCM constitution in individuals with dry eye, offering valuable insights and guiding future TCM-related research in the context of dry eye. Additionally, we established correlations between TCM syndrome patterns and dry eye indicators.
本研究旨在探讨干眼症患者的中医体质。根据 TFO DEWS II 制定的诊断标准，共纳入 114 例干眼症患者。根据干眼症分类标准，将患者分为 3 种不同的干眼症亚型。每位参与者均接受干眼症的全面临床评估，并使用“干眼症中医问卷”评估其中医体质表现。采用九体质评估法进行中医体质分型和分类。采用 Spearman 相关分析探讨中医体质与干眼症亚型、临床指标之间的关系，以及中医证候与干眼症亚型之间的关系。在 114 例患者中，气郁体质最为常见，不同干眼症亚型的体质分布存在差异。血瘀、阴虚、气虚和阳虚体质与 2、4、1、4 个干眼症指标之间存在显著相关性。Spearman 分析显示，50 个中医证候中有 5 个与混合性干眼症相关，5 个与蒸发过强型干眼症相关，3 个与水液缺乏型干眼症相关。进一步采用套索回归和二项无序 logistic 回归分析发现，头晕、腰痛和乏力是混合性和蒸发过强型干眼症的影响因素。本研究广泛研究了干眼症患者的中医体质，为干眼症的中医相关研究提供了有价值的见解，并建立了中医证候与干眼症指标之间的相关性。
