Unidad Médico-Quirúrgica de Enfermedades Respiratorias. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Seville, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
Ann Fam Med. 2024 Sep-Oct;22(5):417-420. doi: 10.1370/afm.3147.
The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers conducted an observational cross-sectional study with patients using a single-dose dry powder inhaler. The weight of the capsule was measured with a precision microbalance before and after inhalation. Ninety-one patients were included, of whom 63 (69.2%) used a transparent capsule. Inhalation with a transparent capsule achieved a weight decrease of 30.1% vs 8.6% for devices with an opaque capsule ( <0.001). These data reinforce the need to provide patients with mechanisms that verify the correct inhalation technique.
本研究旨在测试透明胶囊的使用是否会影响吸入后胶囊的残留重量，以此作为替代不可逆性慢性气道疾病患者吸入药物传递剂量的指标。研究人员对使用单剂量干粉吸入器的患者进行了一项观察性的横断面研究。使用精密微量天平在吸入前后测量胶囊的重量。共纳入 91 例患者，其中 63 例（69.2%）使用透明胶囊。与不透明胶囊（<0.001）相比，使用透明胶囊可使胶囊重量减少 30.1%，而使用不透明胶囊则减少 8.6%。这些数据进一步强调了为患者提供验证正确吸入技术的机制的必要性。
