[不同输注介质和溶液对人血浆激肽释放酶-激肽系统的影响]

[Effect of various infusion media and solutions on the kallikrein-kinin system of human plasma].

作者信息

Dotsenko V L, Morozova N A, Iarovaia G A

出版信息

Vopr Med Khim. 1985 Jul-Aug;31(4):116-21.

Abstract

Activities of prekallikrein and Hageman factor (factor XII) were studied in some natural and artificial infusion media: polyglukine, rheoglumane, gemodes, polypher, gelatinol, saline; in solutions for parenteral nutrition--hydrolysate of casein, aminopeptide, aminokrovine, glucose solutions as well as in 10% NaCl and novocain. All the solutions studied did not affect the purified preparations of prekallikrein, but some of them activated partially purified preparations of Hageman factor. However, all these solutions, except of Ringer solution, activated Hageman factor and prekallikrein in human blood serum. Activation of prekallikrein appears to occur via the active form of Hageman factor. Among the solutions studied casein hydrolysate, 5% glucose, gelatinol and novocain exhibited the highest stimulating effect on Hageman factor and prekallikrein. Possible mechanisms of the activation are discussed.

摘要

在一些天然和人工输液介质中研究了前激肽释放酶和哈格曼因子（因子XII）的活性：聚明胶肽、低分子右旋糖酐、Gemodes、聚酚、明胶水解蛋白、生理盐水；在肠外营养溶液中——酪蛋白水解物、氨基肽、氨基血、葡萄糖溶液以及10%氯化钠和奴夫卡因。所研究的所有溶液均不影响前激肽释放酶的纯化制剂，但其中一些溶液可激活部分纯化的哈格曼因子制剂。然而，除林格溶液外，所有这些溶液均可激活人血清中的哈格曼因子和前激肽释放酶。前激肽释放酶的激活似乎是通过哈格曼因子的活性形式发生的。在所研究的溶液中，酪蛋白水解物、5%葡萄糖、明胶水解蛋白和奴夫卡因对哈格曼因子和前激肽释放酶表现出最高的刺激作用。讨论了可能的激活机制。