Engineering Technology Research Center of Henan Province for Aquatic Animal Cultivation, Engineering Laboratory of Henan Province for Aquatic Animal Disease Control, Observation and Research Station On Water Ecosystem in Danjiangkou Reservoir of Henan Province, College of Fisheries, Henan Normal University, Xinxiang, 453007, China.
School of 3D Printing, Xinxiang University, Xinxiang, 453003, China.
Mol Genet Genomics. 2024 Sep 24;299(1):88. doi: 10.1007/s00438-024-02182-x.
Nanog is a crucial regulatory factor in maintaining the self-renewal and pluripotency of embryonic stem cells. It is involved in various biological processes, such as early embryonic development, cell reprogramming, cell cycle regulation, the proliferation and migration of primordial germ cells. While research on this gene has primarily focused on mammals, there has been a growing interest in studying nanog in fish. However, there is a notable lack of comprehensive reviews regarding this gene in fish, which is essential for guiding future research. This review aims to provide a thorough summary of the gene's structure, expression patterns, functions and regulatory mechanisms in fish. The findings suggest that nanog probably has both conserved and divergent functions in regulating cell pluripotency, early embryonic development, and germ cell development in teleosts compared to other species, including mammals. These insights lay the foundation for future research and applications of the nanog gene, providing a new perspective for understanding the evolution and conserved charactristics of teleost nanog.
Nanog 是维持胚胎干细胞自我更新和多能性的关键调节因子。它参与了多种生物过程，如早期胚胎发育、细胞重编程、细胞周期调控、原始生殖细胞的增殖和迁移。虽然对该基因的研究主要集中在哺乳动物上，但人们对鱼类中的 nanog 研究越来越感兴趣。然而，关于鱼类中该基因的综合综述却明显缺乏，这对于指导未来的研究至关重要。本综述旨在提供关于该基因在鱼类中的结构、表达模式、功能和调控机制的全面总结。研究结果表明，与其他物种（包括哺乳动物）相比，nanog 可能在调控细胞多能性、早期胚胎发育和鱼类生殖细胞发育方面具有保守和分歧的功能。这些研究结果为未来的 nanog 基因研究和应用奠定了基础，为理解鱼类 nanog 的进化和保守特征提供了新的视角。
