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[阿苯达唑所致肝毒性:棘球蚴病治疗的安全替代方案]

[Hepatotoxicity due to albendazole: safe alternatives for echinococcosis therapy].

作者信息

Muana Wilhelm Laura, Bachmann Joschka, Cornberg Markus, Wedemeyer Heiner, Heinrich Bernd

机构信息

Klinik für Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie, Medizinische Hochschule Hannover (MHH), OE 6810, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

出版信息

Inn Med (Heidelb). 2025 Feb;66(2):231-235. doi: 10.1007/s00108-024-01796-y. Epub 2024 Sep 23.

Abstract

Infection with Echinococcus multilocularis leads to the clinical manifestation of alveolar echinococcosis. This is characterized by the formation of alveolar liver tumours, which usually disintegrate necrotically in the course of the disease. Pseudocysts are formed. Especially in the early stages, curative resection followed by long-term treatment with albendazole is recommended. However, the majority of patients are not amenable to curative surgery. In these cases, albendazole therapy is the first-choice treatment. We present a rare case of albendazole-associated hepatitis in a patient with inoperable Echinococcus multilocularis infection, with a favourable outcome following a change in treatment to mebendazole.

摘要

多房棘球绦虫感染会导致泡型棘球蚴病的临床表现。其特征为形成肺泡性肝肿瘤,在疾病过程中这些肿瘤通常会发生坏死崩解,形成假囊肿。特别是在疾病早期,建议进行根治性切除,随后长期使用阿苯达唑治疗。然而,大多数患者不适合进行根治性手术。在这些情况下,阿苯达唑治疗是首选治疗方法。我们报告了一例罕见的阿苯达唑相关性肝炎病例,该患者患有无法手术的多房棘球绦虫感染,在改用甲苯达唑治疗后取得了良好的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e76/11799110/93fb68991920/108_2024_1796_Fig1_HTML.jpg

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