• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[阿苯达唑所致肝毒性：棘球蚴病治疗的安全替代方案]

[Hepatotoxicity due to albendazole: safe alternatives for echinococcosis therapy].

作者信息

Muana Wilhelm Laura, Bachmann Joschka, Cornberg Markus, Wedemeyer Heiner, Heinrich Bernd

机构信息

Klinik für Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie, Medizinische Hochschule Hannover (MHH), OE 6810, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

出版信息

Inn Med (Heidelb). 2025 Feb;66(2):231-235. doi: 10.1007/s00108-024-01796-y. Epub 2024 Sep 23.

DOI:10.1007/s00108-024-01796-y
PMID:39313604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11799110/
Abstract

Infection with Echinococcus multilocularis leads to the clinical manifestation of alveolar echinococcosis. This is characterized by the formation of alveolar liver tumours, which usually disintegrate necrotically in the course of the disease. Pseudocysts are formed. Especially in the early stages, curative resection followed by long-term treatment with albendazole is recommended. However, the majority of patients are not amenable to curative surgery. In these cases, albendazole therapy is the first-choice treatment. We present a rare case of albendazole-associated hepatitis in a patient with inoperable Echinococcus multilocularis infection, with a favourable outcome following a change in treatment to mebendazole.

摘要

多房棘球绦虫感染会导致泡型棘球蚴病的临床表现。其特征为形成肺泡性肝肿瘤，在疾病过程中这些肿瘤通常会发生坏死崩解，形成假囊肿。特别是在疾病早期，建议进行根治性切除，随后长期使用阿苯达唑治疗。然而，大多数患者不适合进行根治性手术。在这些情况下，阿苯达唑治疗是首选治疗方法。我们报告了一例罕见的阿苯达唑相关性肝炎病例，该患者患有无法手术的多房棘球绦虫感染，在改用甲苯达唑治疗后取得了良好的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e76/11799110/77cace68dc10/108_2024_1796_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e76/11799110/93fb68991920/108_2024_1796_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e76/11799110/4d90bef452a6/108_2024_1796_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e76/11799110/77cace68dc10/108_2024_1796_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e76/11799110/93fb68991920/108_2024_1796_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e76/11799110/4d90bef452a6/108_2024_1796_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e76/11799110/77cace68dc10/108_2024_1796_Fig3_HTML.jpg

相似文献

1
[Hepatotoxicity due to albendazole: safe alternatives for echinococcosis therapy].[阿苯达唑所致肝毒性：棘球蚴病治疗的安全替代方案]
Inn Med (Heidelb). 2025 Feb;66(2):231-235. doi: 10.1007/s00108-024-01796-y. Epub 2024 Sep 23.
2
Alveolar echinococcosis in the canton of Geneva between 2010 and 2021: a descriptive analysis.2010年至2021年日内瓦州的肺泡型棘球蚴病：描述性分析
Swiss Med Wkly. 2025 Feb 4;155:3863. doi: 10.57187/s.3863.
3
Treatment of uncomplicated hepatic cystic echinococcosis (hydatid disease).肝包虫病（包虫病）的单纯性肝囊肿的治疗。
Cochrane Database Syst Rev. 2024 Jul 12;7(7):CD015573. doi: 10.1002/14651858.CD015573.
4
Alveolar Echinococcosis: Is Non-Radical Liver Resection a Game Changer in the Current Treatment Approach to Patients with Advanced Alveolar Echinococcosis Disease? Single Center Experience of Poland.肺泡型肝包虫病：对于晚期肺泡型肝包虫病患者，非根治性肝切除术会改变当前的治疗方法吗？波兰单中心经验
Acta Parasitol. 2025 Apr 29;70(3):100. doi: 10.1007/s11686-025-01040-z.
5
Clinical confirmation of an infection with Echinococcus multilocularis (Mongolian genotype): first case report of human alveolar echinococcosis in Inner Mongolia, China.多房棘球绦虫（蒙古基因型）感染的临床确诊：中国内蒙古地区首例人体肺泡型棘球蚴病病例报告
Infect Dis Poverty. 2025 Jul 24;14(1):74. doi: 10.1186/s40249-025-01342-4.
6
Past and present of diagnosis of echinococcosis: A review (1999-2021).棘球蚴病诊断的过去和现在：综述（1999-2021 年）。
Acta Trop. 2023 Jul;243:106925. doi: 10.1016/j.actatropica.2023.106925. Epub 2023 Apr 18.
7
Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis.与人类肺泡型棘球蚴病相关的潜在危险因素：系统评价与荟萃分析。
PLoS Negl Trop Dis. 2017 Jul 17;11(7):e0005801. doi: 10.1371/journal.pntd.0005801. eCollection 2017 Jul.
8
Morphological changes of larval Echinococcus multilocularis in mice treated with albendazole or mebendazole.用阿苯达唑或甲苯达唑治疗的小鼠体内多房棘球绦虫幼虫的形态学变化
J Helminthol. 1998 Dec;72(4):349-54. doi: 10.1017/s0022149x00016722.
9
First molecular confirmed patient of alveolar echinococcosis in India: Case report from a tertiary care hospital in North India.印度首例经分子确诊的肺泡型棘球蚴病患者：来自印度北部一家三级护理医院的病例报告
Indian J Med Microbiol. 2025 Jul-Aug;56:100904. doi: 10.1016/j.ijmmb.2025.100904. Epub 2025 Jul 6.
10
Transcriptomic Profiling Reveals Gene Expression Changes in Mouse Liver Tissue During Alveolar Echinococcosis.转录组分析揭示肺泡型棘球蚴病期间小鼠肝脏组织中的基因表达变化。
Genes (Basel). 2025 Jul 18;16(7):839. doi: 10.3390/genes16070839.

本文引用的文献

1
Observed or Predicted Albendazole Hepatotoxicity as an Indication for a Resection Procedure in Hepatic Hydatid Disease - A Short Series of Cases.观察到或预测到的阿苯达唑肝毒性作为肝包虫病切除手术的指征——一组简短病例系列
Chirurgia (Bucur). 2019 Jul-Aug;114(4):522-527. doi: 10.21614/chirurgia.114.4.524.
2
Echinococcosis: Advances in the 21st Century.包虫病：21 世纪的进展。
Clin Microbiol Rev. 2019 Feb 13;32(2). doi: 10.1128/CMR.00075-18. Print 2019 Mar 20.
3
Comprehensive diagnosis and treatment of alveolar echinococcosis: A single-center, long-term observational study of 312 patients in Germany.
肺泡型棘球蚴病的综合诊断与治疗：德国312例患者的单中心长期观察研究
GMS Infect Dis. 2017 Jan 6;5:Doc01. doi: 10.3205/id000027. eCollection 2017.
4
Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans.《包虫病（棘球蚴病、包虫病）临床诊断与治疗专家共识（2023 版）》
Acta Trop. 2010 Apr;114(1):1-16. doi: 10.1016/j.actatropica.2009.11.001. Epub 2009 Nov 30.
5
Clinical management of cystic echinococcosis: state of the art, problems, and perspectives.囊性棘球蚴病的临床管理：现状、问题与展望
Am J Trop Med Hyg. 2008 Sep;79(3):301-11.
6
WHO classification of alveolar echinococcosis: principles and application.世界卫生组织肺泡型棘球蚴病分类：原则与应用
Parasitol Int. 2006;55 Suppl:S283-7. doi: 10.1016/j.parint.2005.11.041. Epub 2005 Dec 15.
7
Chemotherapy of alveolar echinococcosis. Comparison of plasma mebendazole concentrations in animals and man.泡型包虫病的化疗。动物与人血浆中甲苯达唑浓度的比较。
Eur J Clin Pharmacol. 1981;20(6):427-33. doi: 10.1007/BF00542095.