Jung L, Buchwald I C, Hauck A, Lüthgen M, Jagomast T, Weckmann M, Drömann D, Franzen K F
Medical Clinic III, Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany.
Airway Research Center North (ARNCN), German Center for Lung Research (DZL), Großhansdorf - site Lübeck, Germany.
Tob Use Insights. 2024 Sep 19;17:1179173X241271551. doi: 10.1177/1179173X241271551. eCollection 2024.
E-cigarettes and heated tobacco products (HTPs) are gaining worldwide significance. The tobacco industry is promoting these products as healthier alternatives to conventional cigarettes.
In this four-arm crossover study, we examined the acute effects of cigarette smoking, vaping IQOS, or vaping e-cigarettes (with or without nicotine) on hemodynamics, arterial stiffness, and small airways. Twenty subjects (10 male, 10 female), all occasional smokers, completed each study arm. There was at least a 48 h washout period before each test day. Arterial stiffness and peripheral and central hemodynamics were assessed using Mobil-O-Graph™ (I.E.M., Germany), whereas tremoFlo® c-100 (Thoracic Medical Systems Inc) was used to evaluate the effects on the small airways and resistance.
Cigarettes, IQOS, e-cigarettes containing nicotine, and nicotine-free e-cigarettes had similar effects on peripheral and central hemodynamics as well as on arterial stiffness. We observed a significant increase in all parameters. However, only nicotine-containing products lead to increased bronchial obstruction, higher reactance, and a higher tidal volume.
Therefore, we concluded that cigarettes, IQOS, and e-cigarettes have similar effects on hemodynamics. No differences were observed between the nicotine-containing and nicotine-free e-cigarettes. All nicotine-containing products also influence small airways. These findings suggest that e-cigarettes and HTPs are not healthier alternatives than conventional cigarettes.
电子烟和加热烟草制品（HTPs）在全球范围内的重要性日益凸显。烟草行业将这些产品宣传为比传统卷烟更健康的替代品。
在这项四臂交叉研究中，我们研究了吸卷烟、吸IQOS、吸电子烟（含或不含尼古丁）对血流动力学、动脉僵硬度和小气道的急性影响。20名受试者（10名男性，10名女性），均为偶尔吸烟者，完成了每个研究环节。在每个测试日前至少有48小时的洗脱期。使用Mobil-O-Graph™（德国I.E.M.公司）评估动脉僵硬度以及外周和中心血流动力学，而使用tremoFlo® c-100（胸科医疗系统公司）评估对小气道和阻力的影响。
卷烟、IQOS、含尼古丁电子烟和不含尼古丁电子烟对外周和中心血流动力学以及动脉僵硬度的影响相似。我们观察到所有参数均显著增加。然而，只有含尼古丁的产品会导致支气管阻塞增加、电抗升高和潮气量增加。
因此，我们得出结论，卷烟、IQOS和电子烟对血流动力学的影响相似。含尼古丁电子烟和不含尼古丁电子烟之间未观察到差异。所有含尼古丁的产品也会影响小气道。这些发现表明，电子烟和加热烟草制品并非比传统卷烟更健康的替代品。
