Chiang Kate C, Yokel Robert A, Unrine Jason M, Kalantar-Zadeh Kamyar, Gupta Ajay
University College Dublin School of Medicine, Dublin, Ireland.
Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, 40536-0596.
medRxiv. 2024 Sep 9:2023.09.09.23295298. doi: 10.1101/2023.09.09.23295298.
Ready-to-eat, shelf-stable tortillas contain several phosphorus- and aluminum-containing additives that may increase the risk of adverse events in patients with chronic kidney disease (CKD). The present study analyzes and compares the elemental content of wheat flour and corn tortillas with special reference to dietary aluminum and phosphorus burden. Twenty-one elements were quantified by ICP-MS and ICP-OES in 14 corn and 13 wheat flour tortilla brands purchased from local supermarkets in Southern California. The aluminum and phosphorus concentrations of many ready-to-eat tortilla brands can present a daily dietary load of up to approximately 100 mg aluminum and 700 mg phosphorus based on an average daily tortilla intake of 330 grams. Ready-to-eat wheat flour tortillas generally had more phosphorus than corn tortillas. Tortillas with aluminum listed as a food additive contained a higher aluminum content than those without such listing, exceeding the tolerable weekly intake. Despite conventional wisdom that CKD patients should avoid phosphorus-rich corn tortillas, ready-to-eat wheat flour tortillas consistently had a higher aluminum and phosphorus content due to additives. CKD patients and healthcare providers should pay attention to food labels, and regulatory authorities should monitor the use of approved food additives and mandate food label warnings for patients at risk.
即食型、可长期保存的玉米饼含有几种含磷和铝的添加剂,这可能会增加慢性肾病(CKD)患者发生不良事件的风险。本研究分析并比较了小麦粉玉米饼和玉米玉米饼的元素含量,特别关注膳食铝和磷的负担。通过电感耦合等离子体质谱法(ICP-MS)和电感耦合等离子体发射光谱法(ICP-OES)对从南加州当地超市购买的14个玉米玉米饼品牌和13个小麦粉玉米饼品牌中的21种元素进行了定量分析。基于每日平均食用330克玉米饼的量,许多即食型玉米饼品牌的铝和磷含量可提供高达约100毫克铝和700毫克磷的每日膳食摄入量。即食型小麦粉玉米饼的磷含量通常比玉米玉米饼更高。将铝列为食品添加剂的玉米饼的铝含量高于未列出的玉米饼,超过了每周可耐受摄入量。尽管传统观念认为CKD患者应避免食用富含磷的玉米玉米饼,但由于添加剂的存在,即食型小麦粉玉米饼的铝和磷含量始终较高。CKD患者和医疗服务提供者应注意食品标签,监管机构应监测批准的食品添加剂的使用情况,并要求对有风险的患者设置食品标签警告。