Raji Abdullahi Abdullahi, Dastjerdi Paniz Zarghami, Omar Abdul Rahman
Laboratory of Vaccine and Biomolecules, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.
Department of Veterinary Pathology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria.
Front Vet Sci. 2024 Sep 9;11:1405605. doi: 10.3389/fvets.2024.1405605. eCollection 2024.
The poultry industry, a cornerstone of global food security, faces dynamic challenges exacerbated by viral diseases. This review traces the trajectory of poultry vaccination, evolving from traditional methods to the forefront of innovation Virus-Like Particle (VLP) vaccines. Vaccination has been pivotal in disease control, but traditional vaccines exhibit some limitations. This review examines the emergence of VLPs as a game-changer in poultry vaccination. VLPs, mimicking viruses without replication, offer a safer, targeted alternative with enhanced immunogenicity. The narrative encompasses VLP design principles, production methods, immunogenicity, and efficacy against major poultry viruses. Challenges and prospects are explored, presenting VLP vaccines as a transformative technique in poultry disease control. Understanding their potential empowers industry stakeholders to navigate poultry health management with precision, promising improved welfare, reduced economic losses, and heightened food safety.
家禽产业作为全球粮食安全的基石，面临着由病毒性疾病加剧的动态挑战。本综述追溯了家禽疫苗接种的发展轨迹，从传统方法发展到创新前沿的病毒样颗粒（VLP）疫苗。疫苗接种在疾病控制中一直起着关键作用，但传统疫苗存在一些局限性。本综述探讨了VLP作为家禽疫苗接种变革者的出现。VLP模仿病毒但不进行复制，提供了一种更安全、有针对性的替代方案，具有增强的免疫原性。叙述内容包括VLP的设计原则、生产方法、免疫原性以及对主要家禽病毒的效力。探讨了挑战和前景，将VLP疫苗呈现为家禽疾病控制中的一种变革性技术。了解它们的潜力使行业利益相关者能够精确地应对家禽健康管理，有望改善福利、减少经济损失并提高食品安全。
