Kinami Y, Takashima S, Tanaka T, Arizuka S, Ashida Y, Miyazaki I
Gan To Kagaku Ryoho. 1985 Oct;12(10):1990-8.
Intra-arterial continuous infusion of antineoplastic agents was carried out for 90 patients with cancer of the digestive system at our clinic during the past 16 years. These patients had inoperable, advanced or recurrent tumors in various organs: stomach, colorectum, liver, pancreas and others. 5-fluorouracil, mitomycin C, adriamycin and others were infused, singly or in combination, into the aorta (81 patients), or iliac (3) and hepatic (6) artery over periods varying from 2 to 197 days. Partial response was revealed in 41% of the overall patients, no change in 28% and progressive disease in 31%. There were significant differences in anti-tumor effects and survival curves between terminal and non-terminal patients, or between patients with and without long-term infusion (p less than 0.05-0.005). These results suggest that the performance status of patients and the infusion period both influence the anti-tumor or long-survival effect obtained by this therapy.
在过去16年里，我们诊所对90例消化系统癌症患者进行了动脉内持续输注抗肿瘤药物治疗。这些患者的肿瘤位于胃、结肠直肠、肝脏、胰腺等不同器官，无法手术切除、处于晚期或复发。5-氟尿嘧啶、丝裂霉素C、阿霉素等药物单独或联合注入主动脉（81例患者）、髂动脉（3例）和肝动脉（6例），输注时间从2天到197天不等。总体患者中41%出现部分缓解，28%无变化，31%病情进展。晚期患者与非晚期患者之间，或长期输注患者与未长期输注患者之间，抗肿瘤效果和生存曲线存在显著差异（p<0.05-0.005）。这些结果表明，患者的身体状况和输注时间均会影响该治疗方法的抗肿瘤或长期生存效果。
