Department of Chemistry, Sardar Vallabhbhai National Institute of Technology, Surat, 395007, Gujarat, India.
ASPEE Shakilam Biotechnology Institute, Navsari Agricultural University, Surat, 395007, Gujarat, India.
Mikrochim Acta. 2024 Sep 25;191(10):621. doi: 10.1007/s00604-024-06705-6.
A hydrothermal synthetic method is established to produce blue fluorescent Eu-doped niobium carbide MXene quantum dots (Eu-NbC MQDs). The synthesized Eu-NbC MQDs demonstrated a quantum yield of 20.61% and a maximum emission intensity at 405 nm. The as-prepared Eu-NbC MQDs acted as a sensor for the rapid and sensitive detection of hypoxanthine through fluorescence quenching, and of fluoxetine through fluorescence enhancement mechanisms. The emission peak of Eu-NbC MQDs at 405 nm exhibited a linear response for hypoxanthine and fluoxetine in the ranges of 0.5-25 µM and 0.125-2.5 µM, with detection limits of 15.0 and 3.7 nM, respectively. The newly developed probe was effectively used for the selective detection of hypoxanthine and fluoxetine in biofluids and pharmaceutical samples. Remarkably, the Eu-NbC MQDs exhibited minimal cytotoxicity towards A549 lung cancer cells and showed great potential as imaging agent for imaging of Saccharomyces cerevisiae cells.
建立了一种水热合成方法来制备蓝色荧光 Eu 掺杂碳化铌 MXene 量子点（Eu-NbC MQDs）。所合成的 Eu-NbC MQDs 的量子产率为 20.61%，最大发射强度在 405nm 处。所制备的 Eu-NbC MQDs 可以作为传感器，通过荧光猝灭机制快速灵敏地检测次黄嘌呤，以及通过荧光增强机制检测氟西汀。Eu-NbC MQDs 的发射峰在 405nm 处对次黄嘌呤和氟西汀的线性响应范围分别为 0.5-25µM 和 0.125-2.5µM，检测限分别为 15.0 和 3.7nM。该新型探针可有效地用于生物流体和药物样品中次黄嘌呤和氟西汀的选择性检测。值得注意的是，Eu-NbC MQDs 对 A549 肺癌细胞的细胞毒性很小，并且作为 Saccharomyces cerevisiae 细胞成像的成像剂具有很大的潜力。
