Lu Xiaoxue, Ma Rongrong, Zhan Jinling, Pan Xiaohua, Liu Chang, Zhang Shuang, Tian Yaoqi
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.
School of Food Science and Technology, Jiangnan University, Wuxi, China.
Crit Rev Food Sci Nutr. 2024 Sep 25:1-10. doi: 10.1080/10408398.2024.2407894.
Thermal treatment of food may undergo Maillard reactions and produce harmful substances, e.g., advanced glycation end products (AGEs). Current studies show different results about the effects of dietary AGE intake on the biomarkers of type 2 diabetes mellitus (T2DM). Therefore, this work conducted a systematic review and meta-analysis to explore the effect of dietary AGE intake on the biomarkers of T2DM, the available evidence, and the bias of this evidence. This meta-analysis focused on the association between high AGE intake and fasting plasma glucose, fasting plasma insulin, HbA1c, and HOMA-IR. Thirteen parallel studies and 4 randomized crossover studies were finally included. In the pooled analysis, fasting glucose (SMD: 0.98; 95% CI: 0.23, 1.73; = .011), fasting insulin (SMD: 1.44; 95% CI: 0.63, 2.25; < .01), and HOMA-IR (SMD: 1.47; 95% CI: 0.59, 2.34; < .01) significantly increased after dietary intake with high AGEs. In the subgroup analyses, high-AGE diets and healthy participants were associated with changes in the biomarkers of T2DM. Taken together, the intake of high dietary AGE was related to the development of T2DM.
食物的热处理可能会发生美拉德反应并产生有害物质，例如晚期糖基化终产物（AGEs）。目前的研究对于膳食AGE摄入量对2型糖尿病（T2DM）生物标志物的影响给出了不同的结果。因此，本研究进行了一项系统评价和荟萃分析，以探究膳食AGE摄入量对T2DM生物标志物的影响、现有证据以及该证据的偏差。这项荟萃分析聚焦于高AGE摄入量与空腹血糖、空腹血浆胰岛素、糖化血红蛋白（HbA1c）和胰岛素抵抗稳态模型评估（HOMA-IR）之间的关联。最终纳入了13项平行研究和4项随机交叉研究。在汇总分析中，高AGE膳食摄入后，空腹血糖（标准化均值差：0.98；95%置信区间：0.23，1.73；P = 0.011）、空腹胰岛素（标准化均值差：1.44；95%置信区间：0.63，2.25；P < 0.01）和HOMA-IR（标准化均值差：1.47；95%置信区间：0.59，2.34；P < 0.01）均显著升高。在亚组分析中，高AGE饮食与健康参与者和T2DM生物标志物的变化有关。综上所述，高膳食AGE摄入量与T2DM的发生发展有关。
