State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products/Key Laboratory of Detection for Pesticide Residues and Control of Zhejiang, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, P. R. China.
Agricultural Ministry Key Laboratory for Pesticide Residue Detection, Hangzhou 310021, P. R. China.
J Agric Food Chem. 2024 Oct 9;72(40):22073-22081. doi: 10.1021/acs.jafc.4c05937. Epub 2024 Sep 25.
Isopyrazam (IPZ) is a new chiral fungicide. For bioactivity, there was a 3.37-1578 times difference among the four stereoisomers. For and , -(1,4,9)IPZ had the greatest activity. Using -IPZ might improve the efficacy and reduce the dosage of the racemate by 54.7-72.2% for and . To zebrafish, -IPZ showed the highest acute toxicity (LC, 0.096 mg/L). The degradation half-lives of IPZ stereoisomers in the five crops ranged from 3.50 to 15.2 days. -IPZ was preferentially degraded in grape, pear, and celery. The residual concentrations of IPZ in grape and celery were still higher than the maximum residue limit, and the acute and chronic dietary intake risks of IPZ in celery were unacceptable (RQ: 146-250%, HQ: 117-200%), which were worthy of further researching. Based on the research results, it is safer and more reasonable to use IPZ in the form of a racemate with a high ratio of -IPZ.
异吡唑酰胺（IPZ）是一种新型的手性杀菌剂。在生物活性方面，四种立体异构体之间的差异为 3.37-1578 倍。对于 和 ，-(1,4,9)IPZ 的活性最大。使用 -IPZ 可能会提高药效，并将外消旋体的用量减少 54.7-72.2%。对于斑马鱼，-IPZ 表现出最高的急性毒性（LC，0.096mg/L）。IPZ 立体异构体在五种作物中的降解半衰期从 3.50 到 15.2 天不等。-IPZ 优先在葡萄、梨和芹菜中降解。葡萄和芹菜中 IPZ 的残留浓度仍高于最大残留限量，芹菜中 IPZ 的急性和慢性膳食摄入风险不可接受（RQ：146-250%，HQ：117-200%），值得进一步研究。基于研究结果，以高比例 -IPZ 的外消旋体形式使用 IPZ 更安全、更合理。
