Lichtenberger J, Côté E, Forney S D, Barrett K A, Ettinger S J
Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave, Charlottetown, PE C1A 4P3, Canada.
Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave, Charlottetown, PE C1A 4P3, Canada.
J Vet Cardiol. 2024 Dec;56:56-64. doi: 10.1016/j.jvc.2024.08.007. Epub 2024 Aug 30.
INTRODUCTION/OBJECTIVES: This study evaluated circulating amino-terminal pro-B-type natriuretic peptide (NT-proBNP), amino-terminal pro-A-type natriuretic peptide (NT-proANP), and cardiac troponin I (cTnI) concentrations in dogs with precapillary pulmonary hypertension (Pre-PH) and control dogs with respiratory clinical signs but no Pre-PH.
Twenty-six dogs (17 affected, and nine controls) were involved in the study.
This was a sub-study of a large prospective single-center observational study. Dogs underwent blood sample collection, physical examination, and echocardiographic evaluation. Precapillary pulmonary hypertension was diagnosed when a calculated right ventricular-to-right atrial pressure gradient (RV:RA PG) measuring ≥40 mmHg was identified echocardiographically, barring right ventricular outflow obstruction and/or left-sided cardiac disease.
Two, nine, and six dogs had mild, moderate, and severe Pre-PH, respectively. Plasma concentrations of NT-proBNP, NT-proANP, and cTnI were significantly higher in the affected group than in the control group (P=0.020, P=0.009, P=0.011, respectively). There was a positive correlation between RV:RA PG and NT-proBNP (r = 0.52), NT-proANP (r = 0.54), and cTnI (r = 0.67) concentrations.
Precapillary pulmonary hypertension should be included in the differential diagnosis list of elevated cardiac biomarker concentrations in dogs with respiratory signs.
Strict selection criteria reduced group sizes. There were rare missing data points. The diagnosis of Pre-PH was obtained from Doppler echocardiographic RV:RA PG. The disease process causing Pre-PH was not evaluated histopathologically.
Circulating cardiac biomarker concentrations are increased in dogs with Pre-PH and there is a positive correlation between RV:RA PG and NT-proBNP, NT-proANP, and cTnI concentrations.
引言/目的：本研究评估了毛细血管前性肺动脉高压（Pre-PH）犬与有呼吸道临床症状但无Pre-PH的对照犬的循环氨基末端前B型利钠肽（NT-proBNP）、氨基末端前A型利钠肽（NT-proANP）和心肌肌钙蛋白I（cTnI）浓度。
26只犬（17只患病犬和9只对照犬）参与了本研究。
这是一项大型前瞻性单中心观察性研究的子研究。犬接受了血液样本采集、体格检查和超声心动图评估。当通过超声心动图确定计算出的右心室与右心房压力梯度（RV:RA PG）≥40 mmHg时，诊断为毛细血管前性肺动脉高压，排除右心室流出道梗阻和/或左心疾病。
分别有2只、9只和6只犬患有轻度、中度和重度Pre-PH。患病组血浆NT-proBNP、NT-proANP和cTnI浓度显著高于对照组（P分别为0.020、0.009、0.011）。RV:RA PG与NT-proBNP（r = 0.52）、NT-proANP（r = 0.54）和cTnI（r = 0.67）浓度之间存在正相关。
毛细血管前性肺动脉高压应列入有呼吸道症状犬心脏生物标志物浓度升高的鉴别诊断清单。
严格的选择标准使组规模减小。有极少缺失数据点。Pre-PH的诊断通过多普勒超声心动图RV:RA PG获得。未通过组织病理学评估导致Pre-PH的疾病过程。
Pre-PH犬的循环心脏生物标志物浓度升高，且RV:RA PG与NT-proBNP、NT-proANP和cTnI浓度之间存在正相关。
